Abstract
Background: Non-small cell lung cancer (NSCLC) is uncommonly diagnosed in patients younger than 50 years of age. We analyzed the California Cancer Registry (CCR) to describe epidemiologic characteristics and outcomes in this patient subset and to identify factors prognostic for cause-specific survival (CSS). Methods: Patients diagnosed with NSCLC between 1/1/98 through 12/31/09 and reported to the (CCR) as of October 2011 were included. The primary outcome measure was CSS. Cox regression models were used to evaluate predictors of CSS in young patients with NSCLC, adjusted for potential confounders. Interaction analysis was performed between age groups (<50 vs. ≥50) and specific demographic and tumor covariates. Results: We identified 132,671 lung cancer cases, of which 114,451 (86.3%) had NSCLC. Of these, 6389 (5.6%) were < 50 years of age (median, 46 years). The most common histology was adenocarcinoma (3697, 57.9%). Most patients had stage III (1522, 23.8%) or IV (3655, 57.2%) disease. Fewer young patients were diagnosed in recent years (n, % of total NSCLC population of that era): 1998-2001 (2355, 6.0), 2002-2005 (2182, 5.7), and 2006-2009 (1852, 5.0), P< 0.001. Multivariate analysis showed that age <50 years was an independent predictor of improved CSS (HR 0.827, P< 0.001). Significant predictors of better CSS in patients <50 years included female sex, Asian or Hispanic ethnicity, lower stage, later year of diagnosis, and higher socioeconomic status, among others. Adenocarcinoma histology was not associated with improved CSS in this patient subset (HR 0.987, P= 0.78). Interaction analysis revealed that Hispanic race and bronchioloalveolar histology had differential CSS outcomes dependent on age group. Conclusions: This large registry study found that age <50 years is an independent predictor of improved CSS. Variables prognostic for CSS differed somewhat from those in older patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 264-269 |
| Number of pages | 6 |
| Journal | Lung Cancer |
| Volume | 85 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2014 |
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Keywords
- Cause specific survival
- Epidemiology
- Non-small cell lung cancer
- Prognosis
- Registry analysis
- Young patients
ASJC Scopus subject areas
- Oncology
- Pulmonary and Respiratory Medicine
- Cancer Research
Cite this
Predictors of survival for younger patients less than 50 years of age with non-small cell lung cancer (NSCLC) : A California Cancer Registry analysis. / Lara, Matthew S.; Brunson, Ann; Wun, Theodore; Tomlinson, Ben; Qi, Lihong; Cress, Rosemary D; Gandara, David R; Kelly, Karen.
In: Lung Cancer, Vol. 85, No. 2, 2014, p. 264-269.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Predictors of survival for younger patients less than 50 years of age with non-small cell lung cancer (NSCLC)
T2 - A California Cancer Registry analysis
AU - Lara, Matthew S.
AU - Brunson, Ann
AU - Wun, Theodore
AU - Tomlinson, Ben
AU - Qi, Lihong
AU - Cress, Rosemary D
AU - Gandara, David R
AU - Kelly, Karen
PY - 2014
Y1 - 2014
N2 - Background: Non-small cell lung cancer (NSCLC) is uncommonly diagnosed in patients younger than 50 years of age. We analyzed the California Cancer Registry (CCR) to describe epidemiologic characteristics and outcomes in this patient subset and to identify factors prognostic for cause-specific survival (CSS). Methods: Patients diagnosed with NSCLC between 1/1/98 through 12/31/09 and reported to the (CCR) as of October 2011 were included. The primary outcome measure was CSS. Cox regression models were used to evaluate predictors of CSS in young patients with NSCLC, adjusted for potential confounders. Interaction analysis was performed between age groups (<50 vs. ≥50) and specific demographic and tumor covariates. Results: We identified 132,671 lung cancer cases, of which 114,451 (86.3%) had NSCLC. Of these, 6389 (5.6%) were < 50 years of age (median, 46 years). The most common histology was adenocarcinoma (3697, 57.9%). Most patients had stage III (1522, 23.8%) or IV (3655, 57.2%) disease. Fewer young patients were diagnosed in recent years (n, % of total NSCLC population of that era): 1998-2001 (2355, 6.0), 2002-2005 (2182, 5.7), and 2006-2009 (1852, 5.0), P< 0.001. Multivariate analysis showed that age <50 years was an independent predictor of improved CSS (HR 0.827, P< 0.001). Significant predictors of better CSS in patients <50 years included female sex, Asian or Hispanic ethnicity, lower stage, later year of diagnosis, and higher socioeconomic status, among others. Adenocarcinoma histology was not associated with improved CSS in this patient subset (HR 0.987, P= 0.78). Interaction analysis revealed that Hispanic race and bronchioloalveolar histology had differential CSS outcomes dependent on age group. Conclusions: This large registry study found that age <50 years is an independent predictor of improved CSS. Variables prognostic for CSS differed somewhat from those in older patients.
AB - Background: Non-small cell lung cancer (NSCLC) is uncommonly diagnosed in patients younger than 50 years of age. We analyzed the California Cancer Registry (CCR) to describe epidemiologic characteristics and outcomes in this patient subset and to identify factors prognostic for cause-specific survival (CSS). Methods: Patients diagnosed with NSCLC between 1/1/98 through 12/31/09 and reported to the (CCR) as of October 2011 were included. The primary outcome measure was CSS. Cox regression models were used to evaluate predictors of CSS in young patients with NSCLC, adjusted for potential confounders. Interaction analysis was performed between age groups (<50 vs. ≥50) and specific demographic and tumor covariates. Results: We identified 132,671 lung cancer cases, of which 114,451 (86.3%) had NSCLC. Of these, 6389 (5.6%) were < 50 years of age (median, 46 years). The most common histology was adenocarcinoma (3697, 57.9%). Most patients had stage III (1522, 23.8%) or IV (3655, 57.2%) disease. Fewer young patients were diagnosed in recent years (n, % of total NSCLC population of that era): 1998-2001 (2355, 6.0), 2002-2005 (2182, 5.7), and 2006-2009 (1852, 5.0), P< 0.001. Multivariate analysis showed that age <50 years was an independent predictor of improved CSS (HR 0.827, P< 0.001). Significant predictors of better CSS in patients <50 years included female sex, Asian or Hispanic ethnicity, lower stage, later year of diagnosis, and higher socioeconomic status, among others. Adenocarcinoma histology was not associated with improved CSS in this patient subset (HR 0.987, P= 0.78). Interaction analysis revealed that Hispanic race and bronchioloalveolar histology had differential CSS outcomes dependent on age group. Conclusions: This large registry study found that age <50 years is an independent predictor of improved CSS. Variables prognostic for CSS differed somewhat from those in older patients.
KW - Cause specific survival
KW - Epidemiology
KW - Non-small cell lung cancer
KW - Prognosis
KW - Registry analysis
KW - Young patients
UR - http://www.scopus.com/inward/record.url?scp=84904091975&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84904091975&partnerID=8YFLogxK
U2 - 10.1016/j.lungcan.2014.04.007
DO - 10.1016/j.lungcan.2014.04.007
M3 - Article
C2 - 24878033
AN - SCOPUS:84904091975
VL - 85
SP - 264
EP - 269
JO - Lung Cancer
JF - Lung Cancer
SN - 0169-5002
IS - 2
ER -