Predictors of recurrence in the management of chordoid meningioma

Winward Choy, Leonel Ampie, Jonathan B. Lamano, Kartik Kesavabhotla, Qinwen Mao, Andrew T. Parsa, Orin Bloch

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Management of chordoid meningiomas (CMs) is complicated by high rates of recurrence, particularly following subtotal resection. Optimal management is not established given the paucity of published experience. To identify prognostic factors for recurrence following resection, the authors conducted the largest systematic review of CMs to date. A comprehensive search on MEDLINE (OVID and Pubmed), Scopus, Embase, and Web of Science utilizing the search terms “chordoid” AND “meningioma” was performed to identify all reports of pathologically confirmed intracranial CMs. A total of 221 patients were included, comprising 120 females and 101 males. Mean age, MIB-1/Ki67, and tumor size was 45.5 years, 4.3 % (range 0.1–26.6 %), and 4.1 cm (range 0.8–10 cm), respectively. 5-, and 10- year progression free survival was 67.5 and 54.4 %, respectively. Gross total resection (GTR) and subtotal resection was achieved in 172 and 48 patients, respectively. Adjuvant radiotherapy (RT) was given to 30 patients. Multivariate analysis found GTR was strongly correlated with decreased recurrence rates (HR 0.04, p = <0.0001), while higher MIB-1 labeling index (≥5 vs <5 %) was associated with increased recurrence (HR 7.08; p = 0.016). Adjuvant RT, age, gender, and tumor location were not associated with recurrence. GTR resection is the strongest predictor of tumor control, and should be the goal to minimize local progression. Additionally, higher MIB-1 labeling was associated with increased rates of tumor recurrence. Tumors that are subtotally resected or demonstrate higher MIB-1 are at greater recurrence and warrant consideration for RT and close long term follow up.

Original languageEnglish (US)
Pages (from-to)107-116
Number of pages10
JournalJournal of Neuro-Oncology
Issue number1
StatePublished - Jan 1 2016
Externally publishedYes


  • Atypical
  • Chordoid
  • Meningioma
  • Radiation therapy
  • Surgery

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research


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