Predictors of Health-Related Quality of Life and Adherence in Crohn’s Disease and Ulcerative Colitis: Implications for Clinical Management

Anilga Tabibian, James H. Tabibian, Linda J. Beckman, Laura L. Raffals, Konstantinos A. Papadakis, Sunanda V. Kane

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background and Aims: Inflammatory bowel disease (IBD) is associated with impaired health-related quality of life (HRQOL) and adherence. Our aim was to identify demographic, clinical, and psychosocial predictors of impaired HRQOL and non-adherence to provider recommendations. Methods: Adults with Crohn’s disease (CD) or ulcerative colitis (UC) residing within the USA were recruited from online IBD support groups for participation in this cross-sectional study. Data were collected online through standardized instruments, including the Inflammatory Bowel Disease Questionnaire and the Medical Outcomes Study (MOS) general adherence scale. Bivariate analyses and multivariate linear regression were used to assess predictors of HRQOL and adherence. Results: We recruited 136 individuals, among whom median age was 35 years (range 18–75), and 82 % were female. 57 % had CD, and 43 % had UC. Predictors of lower HRQOL among CD patients were perceived stress (p < 0.0001), number of CD relapses (p < 0.0001), and female gender (p = 0.0015), while among UC patients they were perceived stress (p < 0.0001) and number of UC relapses (p = 0.0017). Predictors of lower adherence to provider recommendations in CD were perceived stress (p = 0.0007) and older age (p = 0.041), while in UC, perceived stress was the only predictor of lower adherence (p = 0.022). Conclusions: Among patients with IBD, a higher level of perceived stress is a strong predictor of lower HRQOL and lower adherence to provider recommendations. Additionally, females with CD and patients with higher number of IBD relapses may be at risk of lower HRQOL. Psychological interventions, including physician-facilitated conversations, psychological screeners, and a multidisciplinary approach, may help address impaired HRQOL and adherence and merit further study.

Original languageEnglish (US)
Pages (from-to)1366-1374
Number of pages9
JournalDigestive Diseases and Sciences
Volume60
Issue number5
DOIs
StatePublished - May 1 2015
Externally publishedYes

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Ulcerative Colitis
Crohn Disease
Quality of Life
Inflammatory Bowel Diseases
Recurrence
Psychology
Self-Help Groups
Linear Models
Multivariate Analysis
Cross-Sectional Studies
Demography
Outcome Assessment (Health Care)
Physicians

Keywords

  • Inflammatory bowel disease
  • Integrated care
  • Patient education
  • Perceived stress

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology
  • Medicine(all)

Cite this

Predictors of Health-Related Quality of Life and Adherence in Crohn’s Disease and Ulcerative Colitis : Implications for Clinical Management. / Tabibian, Anilga; Tabibian, James H.; Beckman, Linda J.; Raffals, Laura L.; Papadakis, Konstantinos A.; Kane, Sunanda V.

In: Digestive Diseases and Sciences, Vol. 60, No. 5, 01.05.2015, p. 1366-1374.

Research output: Contribution to journalArticle

Tabibian, Anilga ; Tabibian, James H. ; Beckman, Linda J. ; Raffals, Laura L. ; Papadakis, Konstantinos A. ; Kane, Sunanda V. / Predictors of Health-Related Quality of Life and Adherence in Crohn’s Disease and Ulcerative Colitis : Implications for Clinical Management. In: Digestive Diseases and Sciences. 2015 ; Vol. 60, No. 5. pp. 1366-1374.
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AU - Beckman, Linda J.

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AU - Papadakis, Konstantinos A.

AU - Kane, Sunanda V.

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