Predictors of cobalamin deficiency in Guatemalan school children: Diet, Helicobacter pylori, or bacterial overgrowth?

Lisa M. Rogers, Erick Boy, Joshua W. Miller, Ralph Green, Monica Rodriguez, Francisco Chew, Lindsay H. Allen

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objectives: The authors investigated whether low vitamin B12 intake, impaired gastric function, Helicobacter pylori infection, and bacterial overgrowth were risk factors for the high prevalence of cobalamin deficiency observed in Guatemalan children. Methods: The plasma cobalamin concentration of 556 school children was measured and classified as low, marginal, or adequate. In 60 children from each of these three groups, concentrations of serum methylmalonic acid (MMA), plasma homocysteine, and plasma holotranscobalamin II were measured, and usual dietary B12 intake was estimated. Serum gastrin and pepsinogen I concentrations were measured, and H. pylori and bacterial overgrowth were diagnosed using 13C-urea and 13C-xylose breath tests, respectively. Results: H. pylori infection was present in 83% (144 of 174) of children, and bacterial overgrowth was found in 25% (28 of 113). Children with H. pylori infection had higher serum gastrin and pepsinogen I. There were no significant differences among the plasma cobalamin groups in the prevalence of H. pylori infection, bacterial overgrowth, serum gastrin, or pepsinogen I concentrations. However, there was a significant positive correlation between serum MMA and gastrin concentrations. The average daily consumption of dietary B12 was 5.5 ± 5.2 μg/day, but intakes for 23% of children were <1.8 μg/day. B12 intake from fortified snacks added an additional 0.3 ± 0.2 μg/day. B12 intake was not significantly different among the plasma cobalamin groups, but it was significantly correlated with plasma cobalamin. Conclusions: The specific cause of cobalamin deficiency in this population remains unclear, but these results suggest that low dietary B12 intake is a risk factor and alterations in gastric secretions may also play a role.

Original languageEnglish (US)
Pages (from-to)27-36
Number of pages10
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume36
Issue number1
DOIs
StatePublished - Jan 2003

Fingerprint

school children
Helicobacter pylori
vitamin B12
Vitamin B 12
gastrins
Diet
Helicobacter Infections
Pepsinogen A
pepsinogen
diet
Methylmalonic Acid
methylmalonic acid
Serum
Stomach
stomach
risk factors
infection
breath tests
Snacks
Breath Tests

Keywords

  • Bacterial overgrowth
  • Gastrin
  • Helicobacter pylori
  • Pepsinogen I
  • Vitamin B

ASJC Scopus subject areas

  • Gastroenterology
  • Histology
  • Medicine (miscellaneous)
  • Food Science
  • Pediatrics, Perinatology, and Child Health

Cite this

Predictors of cobalamin deficiency in Guatemalan school children : Diet, Helicobacter pylori, or bacterial overgrowth? / Rogers, Lisa M.; Boy, Erick; Miller, Joshua W.; Green, Ralph; Rodriguez, Monica; Chew, Francisco; Allen, Lindsay H.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 36, No. 1, 01.2003, p. 27-36.

Research output: Contribution to journalArticle

Rogers, Lisa M. ; Boy, Erick ; Miller, Joshua W. ; Green, Ralph ; Rodriguez, Monica ; Chew, Francisco ; Allen, Lindsay H. / Predictors of cobalamin deficiency in Guatemalan school children : Diet, Helicobacter pylori, or bacterial overgrowth?. In: Journal of Pediatric Gastroenterology and Nutrition. 2003 ; Vol. 36, No. 1. pp. 27-36.
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abstract = "Objectives: The authors investigated whether low vitamin B12 intake, impaired gastric function, Helicobacter pylori infection, and bacterial overgrowth were risk factors for the high prevalence of cobalamin deficiency observed in Guatemalan children. Methods: The plasma cobalamin concentration of 556 school children was measured and classified as low, marginal, or adequate. In 60 children from each of these three groups, concentrations of serum methylmalonic acid (MMA), plasma homocysteine, and plasma holotranscobalamin II were measured, and usual dietary B12 intake was estimated. Serum gastrin and pepsinogen I concentrations were measured, and H. pylori and bacterial overgrowth were diagnosed using 13C-urea and 13C-xylose breath tests, respectively. Results: H. pylori infection was present in 83{\%} (144 of 174) of children, and bacterial overgrowth was found in 25{\%} (28 of 113). Children with H. pylori infection had higher serum gastrin and pepsinogen I. There were no significant differences among the plasma cobalamin groups in the prevalence of H. pylori infection, bacterial overgrowth, serum gastrin, or pepsinogen I concentrations. However, there was a significant positive correlation between serum MMA and gastrin concentrations. The average daily consumption of dietary B12 was 5.5 ± 5.2 μg/day, but intakes for 23{\%} of children were <1.8 μg/day. B12 intake from fortified snacks added an additional 0.3 ± 0.2 μg/day. B12 intake was not significantly different among the plasma cobalamin groups, but it was significantly correlated with plasma cobalamin. Conclusions: The specific cause of cobalamin deficiency in this population remains unclear, but these results suggest that low dietary B12 intake is a risk factor and alterations in gastric secretions may also play a role.",
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T2 - Diet, Helicobacter pylori, or bacterial overgrowth?

AU - Rogers, Lisa M.

AU - Boy, Erick

AU - Miller, Joshua W.

AU - Green, Ralph

AU - Rodriguez, Monica

AU - Chew, Francisco

AU - Allen, Lindsay H.

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AB - Objectives: The authors investigated whether low vitamin B12 intake, impaired gastric function, Helicobacter pylori infection, and bacterial overgrowth were risk factors for the high prevalence of cobalamin deficiency observed in Guatemalan children. Methods: The plasma cobalamin concentration of 556 school children was measured and classified as low, marginal, or adequate. In 60 children from each of these three groups, concentrations of serum methylmalonic acid (MMA), plasma homocysteine, and plasma holotranscobalamin II were measured, and usual dietary B12 intake was estimated. Serum gastrin and pepsinogen I concentrations were measured, and H. pylori and bacterial overgrowth were diagnosed using 13C-urea and 13C-xylose breath tests, respectively. Results: H. pylori infection was present in 83% (144 of 174) of children, and bacterial overgrowth was found in 25% (28 of 113). Children with H. pylori infection had higher serum gastrin and pepsinogen I. There were no significant differences among the plasma cobalamin groups in the prevalence of H. pylori infection, bacterial overgrowth, serum gastrin, or pepsinogen I concentrations. However, there was a significant positive correlation between serum MMA and gastrin concentrations. The average daily consumption of dietary B12 was 5.5 ± 5.2 μg/day, but intakes for 23% of children were <1.8 μg/day. B12 intake from fortified snacks added an additional 0.3 ± 0.2 μg/day. B12 intake was not significantly different among the plasma cobalamin groups, but it was significantly correlated with plasma cobalamin. Conclusions: The specific cause of cobalamin deficiency in this population remains unclear, but these results suggest that low dietary B12 intake is a risk factor and alterations in gastric secretions may also play a role.

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