Prediction of myelotoxicity using semi-quantitative marrow image scores

S. Lim, G. L. DeNardo, D. A. DeNardo, R. T. O'Donnell, A. Yuan, S. J. DeNardo

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Marrow radiation with resultant myelosuppression is usually dose- limiting in radioimmunotherapy (RIT). This study evaluated the relationship between a semiquantitative score of radiolabeled antibody marrow uptake obtained by imaging and subsequent decrease in peripheral blood cell counts in a patient population in whom marrow malignancy is common. Methods: Semiquantitative scores were assigned to lumbar marrow images of 18 patients acquired 0, 6, 24 and 48 hr after the first therapy dose of 131I-Lym-1. Scores were adjusted for injected dose (GBq) and body surface area (m2), and correlated with post-therapy blood counts. A well-defined scale, where 0 and 4 represented least to highest marrow uptake when compared to background, was used to assign marrow image scores. Injected doses of 131I-Lym-1 ranged from 1.1-8.2 GBq (29-222 mCi). Results: Linear regression of summed marrow scores (0-24 hr after injection) versus decrease in cell counts produced correlation coefficients of 0.76, 0.44, 0.58 and 0.46 for platelets, granulocytes, white blood cells (WBC) and hematocrit, respectively. Scores for individual and other combinations of images obtained immediately up to 24 hr after injection were also predictive.

Original languageEnglish (US)
Pages (from-to)1749-1753
Number of pages5
JournalJournal of Nuclear Medicine
Volume38
Issue number11
StatePublished - Nov 1997

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Keywords

  • Marrow imaging
  • Myelotoxicity
  • Radioimmunotherapy
  • Semiquantitative

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

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