Prediction of flunixin tissue residue concentrations in livers from diseased cattle

H. Wu, R. E. Baynes, Lisa A Tell, J. E. Riviere

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Flunixin, a widely used non-steroidal anti-inflammatory drug, was a leading cause of violative residues in cattle. The objective of this analysis was to explore how the changes in pharmacokinetic (PK) parameters that may be associated with diseased animals affect the predicted liver residue of flunixin in cattle. Monte Carlo simulations for liver residues of flunixin were performed using the PK model structure and relevant PK parameter estimates from a previously published population PK model for flunixin in cattle. The magnitude of a change in the PK parameter value that resulted in a violative residue issue in more than one percent of a cattle population was compared. In this regard, elimination clearance and volume of distribution affected withdrawal times. Pathophysiological factors that can change these parameters may contribute to the occurrence of violative residues of flunixin.

Original languageEnglish (US)
Pages (from-to)876-879
Number of pages4
JournalFood and Chemical Toxicology
Volume62
DOIs
StatePublished - 2013

Fingerprint

flunixin
Pharmacokinetics
Liver
pharmacokinetics
Liver Diseases
Tissue
liver
prediction
cattle
Animal Diseases
nonsteroidal anti-inflammatory agents
Model structures
Population
Animals
Anti-Inflammatory Agents
tissues
Pharmaceutical Preparations
animals

Keywords

  • Flunixin
  • Monte Carlo simulation
  • Population pharmacokinetics
  • Tissue residue

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

Prediction of flunixin tissue residue concentrations in livers from diseased cattle. / Wu, H.; Baynes, R. E.; Tell, Lisa A; Riviere, J. E.

In: Food and Chemical Toxicology, Vol. 62, 2013, p. 876-879.

Research output: Contribution to journalArticle

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