Prediction of cognitive decline in normal elderly subjects with 2-[18F]fluoro-2-deoxy-D-glucose/positron-emission tomography (FDG/PET)

M. J. De Leon, A. Convit, O. T. Wolf, C. Y. Tarshish, S. DeSanti, H. Rusinek, W. Tsui, E. Kandil, A. J. Scherer, A. Roche, A. Imossi, E. Thorn, Matthew Bobinski, C. Caraos, P. Lesbre, D. Schlyer, J. Poirier, B. Reisberg, J. Fowler

Research output: Contribution to journalArticle

511 Citations (Scopus)

Abstract

Neuropathology studies show that patients with mild cognitive impairment (MCI) and Alzheimer's disease typically have lesions of the entorhinal cortex (EC), hippocampus (Hip), and temporal neocortex. Related observations with in vivo imaging have enabled the prediction of dementia from MCI. Although individuals with normal cognition may have focal EC lesions, this anatomy has not been studied as a predictor of cognitive decline and brain change. The objective of this MRI-guided 2-[18F]fluoro-2-deoxy -D-glucose/positron-emission tomography (FDG/PET) study was to examine the hypothesis that among normal elderly subjects, EC METglu reductions predict decline and the involvement of the Hip and neocortex. In a 3-year longitudinal study of 48 healthy normal elderly, 12 individuals (mean age 72) demonstrated cognitive decline (11 to MCI and 1 to Alzheimer's disease). Nondeclining controls were matched on apolipoprotein E genotype, age, education, and gender. At baseline, metabolic reductions in the EC accurately predicted the conversion from normal to MCI. Among those who declined, the baseline EC predicted longitudinal memory and temporal neocortex metabolic reductions. At follow-up, those who declined showed memory impairment and hypometabolism in temporal lobe neocortex and Hip. Among those subjects who declined, apolipoprotein E E4 carriers showed marked longitudinal temporal neocortex reductions. In summary, these data suggest that an EC stage of brain involvement can be detected in normal elderly that predicts future cognitive and brain metabolism reductions. Progressive E4-related hypometabolism may underlie the known increased susceptibility for dementia. Further study is required to estimate individual risks and to determine the physiologic basis for METglu changes detected while cognition is normal.

Original languageEnglish (US)
Pages (from-to)10966-10971
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume98
Issue number19
DOIs
StatePublished - Sep 11 2001
Externally publishedYes

Fingerprint

Entorhinal Cortex
Fluorodeoxyglucose F18
Positron-Emission Tomography
Neocortex
Hippocampus
Apolipoproteins E
Cognition
Dementia
Brain
Apolipoprotein E4
Temporal Lobe
Longitudinal Studies
Cognitive Dysfunction
Anatomy
Alzheimer Disease
Genotype
Education

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Prediction of cognitive decline in normal elderly subjects with 2-[18F]fluoro-2-deoxy-D-glucose/positron-emission tomography (FDG/PET). / De Leon, M. J.; Convit, A.; Wolf, O. T.; Tarshish, C. Y.; DeSanti, S.; Rusinek, H.; Tsui, W.; Kandil, E.; Scherer, A. J.; Roche, A.; Imossi, A.; Thorn, E.; Bobinski, Matthew; Caraos, C.; Lesbre, P.; Schlyer, D.; Poirier, J.; Reisberg, B.; Fowler, J.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, No. 19, 11.09.2001, p. 10966-10971.

Research output: Contribution to journalArticle

De Leon, MJ, Convit, A, Wolf, OT, Tarshish, CY, DeSanti, S, Rusinek, H, Tsui, W, Kandil, E, Scherer, AJ, Roche, A, Imossi, A, Thorn, E, Bobinski, M, Caraos, C, Lesbre, P, Schlyer, D, Poirier, J, Reisberg, B & Fowler, J 2001, 'Prediction of cognitive decline in normal elderly subjects with 2-[18F]fluoro-2-deoxy-D-glucose/positron-emission tomography (FDG/PET)', Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 19, pp. 10966-10971. https://doi.org/10.1073/pnas.191044198
De Leon, M. J. ; Convit, A. ; Wolf, O. T. ; Tarshish, C. Y. ; DeSanti, S. ; Rusinek, H. ; Tsui, W. ; Kandil, E. ; Scherer, A. J. ; Roche, A. ; Imossi, A. ; Thorn, E. ; Bobinski, Matthew ; Caraos, C. ; Lesbre, P. ; Schlyer, D. ; Poirier, J. ; Reisberg, B. ; Fowler, J. / Prediction of cognitive decline in normal elderly subjects with 2-[18F]fluoro-2-deoxy-D-glucose/positron-emission tomography (FDG/PET). In: Proceedings of the National Academy of Sciences of the United States of America. 2001 ; Vol. 98, No. 19. pp. 10966-10971.
@article{2ebc19395a3142b189549f146317a97c,
title = "Prediction of cognitive decline in normal elderly subjects with 2-[18F]fluoro-2-deoxy-D-glucose/positron-emission tomography (FDG/PET)",
abstract = "Neuropathology studies show that patients with mild cognitive impairment (MCI) and Alzheimer's disease typically have lesions of the entorhinal cortex (EC), hippocampus (Hip), and temporal neocortex. Related observations with in vivo imaging have enabled the prediction of dementia from MCI. Although individuals with normal cognition may have focal EC lesions, this anatomy has not been studied as a predictor of cognitive decline and brain change. The objective of this MRI-guided 2-[18F]fluoro-2-deoxy -D-glucose/positron-emission tomography (FDG/PET) study was to examine the hypothesis that among normal elderly subjects, EC METglu reductions predict decline and the involvement of the Hip and neocortex. In a 3-year longitudinal study of 48 healthy normal elderly, 12 individuals (mean age 72) demonstrated cognitive decline (11 to MCI and 1 to Alzheimer's disease). Nondeclining controls were matched on apolipoprotein E genotype, age, education, and gender. At baseline, metabolic reductions in the EC accurately predicted the conversion from normal to MCI. Among those who declined, the baseline EC predicted longitudinal memory and temporal neocortex metabolic reductions. At follow-up, those who declined showed memory impairment and hypometabolism in temporal lobe neocortex and Hip. Among those subjects who declined, apolipoprotein E E4 carriers showed marked longitudinal temporal neocortex reductions. In summary, these data suggest that an EC stage of brain involvement can be detected in normal elderly that predicts future cognitive and brain metabolism reductions. Progressive E4-related hypometabolism may underlie the known increased susceptibility for dementia. Further study is required to estimate individual risks and to determine the physiologic basis for METglu changes detected while cognition is normal.",
author = "{De Leon}, {M. J.} and A. Convit and Wolf, {O. T.} and Tarshish, {C. Y.} and S. DeSanti and H. Rusinek and W. Tsui and E. Kandil and Scherer, {A. J.} and A. Roche and A. Imossi and E. Thorn and Matthew Bobinski and C. Caraos and P. Lesbre and D. Schlyer and J. Poirier and B. Reisberg and J. Fowler",
year = "2001",
month = "9",
day = "11",
doi = "10.1073/pnas.191044198",
language = "English (US)",
volume = "98",
pages = "10966--10971",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "19",

}

TY - JOUR

T1 - Prediction of cognitive decline in normal elderly subjects with 2-[18F]fluoro-2-deoxy-D-glucose/positron-emission tomography (FDG/PET)

AU - De Leon, M. J.

AU - Convit, A.

AU - Wolf, O. T.

AU - Tarshish, C. Y.

AU - DeSanti, S.

AU - Rusinek, H.

AU - Tsui, W.

AU - Kandil, E.

AU - Scherer, A. J.

AU - Roche, A.

AU - Imossi, A.

AU - Thorn, E.

AU - Bobinski, Matthew

AU - Caraos, C.

AU - Lesbre, P.

AU - Schlyer, D.

AU - Poirier, J.

AU - Reisberg, B.

AU - Fowler, J.

PY - 2001/9/11

Y1 - 2001/9/11

N2 - Neuropathology studies show that patients with mild cognitive impairment (MCI) and Alzheimer's disease typically have lesions of the entorhinal cortex (EC), hippocampus (Hip), and temporal neocortex. Related observations with in vivo imaging have enabled the prediction of dementia from MCI. Although individuals with normal cognition may have focal EC lesions, this anatomy has not been studied as a predictor of cognitive decline and brain change. The objective of this MRI-guided 2-[18F]fluoro-2-deoxy -D-glucose/positron-emission tomography (FDG/PET) study was to examine the hypothesis that among normal elderly subjects, EC METglu reductions predict decline and the involvement of the Hip and neocortex. In a 3-year longitudinal study of 48 healthy normal elderly, 12 individuals (mean age 72) demonstrated cognitive decline (11 to MCI and 1 to Alzheimer's disease). Nondeclining controls were matched on apolipoprotein E genotype, age, education, and gender. At baseline, metabolic reductions in the EC accurately predicted the conversion from normal to MCI. Among those who declined, the baseline EC predicted longitudinal memory and temporal neocortex metabolic reductions. At follow-up, those who declined showed memory impairment and hypometabolism in temporal lobe neocortex and Hip. Among those subjects who declined, apolipoprotein E E4 carriers showed marked longitudinal temporal neocortex reductions. In summary, these data suggest that an EC stage of brain involvement can be detected in normal elderly that predicts future cognitive and brain metabolism reductions. Progressive E4-related hypometabolism may underlie the known increased susceptibility for dementia. Further study is required to estimate individual risks and to determine the physiologic basis for METglu changes detected while cognition is normal.

AB - Neuropathology studies show that patients with mild cognitive impairment (MCI) and Alzheimer's disease typically have lesions of the entorhinal cortex (EC), hippocampus (Hip), and temporal neocortex. Related observations with in vivo imaging have enabled the prediction of dementia from MCI. Although individuals with normal cognition may have focal EC lesions, this anatomy has not been studied as a predictor of cognitive decline and brain change. The objective of this MRI-guided 2-[18F]fluoro-2-deoxy -D-glucose/positron-emission tomography (FDG/PET) study was to examine the hypothesis that among normal elderly subjects, EC METglu reductions predict decline and the involvement of the Hip and neocortex. In a 3-year longitudinal study of 48 healthy normal elderly, 12 individuals (mean age 72) demonstrated cognitive decline (11 to MCI and 1 to Alzheimer's disease). Nondeclining controls were matched on apolipoprotein E genotype, age, education, and gender. At baseline, metabolic reductions in the EC accurately predicted the conversion from normal to MCI. Among those who declined, the baseline EC predicted longitudinal memory and temporal neocortex metabolic reductions. At follow-up, those who declined showed memory impairment and hypometabolism in temporal lobe neocortex and Hip. Among those subjects who declined, apolipoprotein E E4 carriers showed marked longitudinal temporal neocortex reductions. In summary, these data suggest that an EC stage of brain involvement can be detected in normal elderly that predicts future cognitive and brain metabolism reductions. Progressive E4-related hypometabolism may underlie the known increased susceptibility for dementia. Further study is required to estimate individual risks and to determine the physiologic basis for METglu changes detected while cognition is normal.

UR - http://www.scopus.com/inward/record.url?scp=0035845499&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035845499&partnerID=8YFLogxK

U2 - 10.1073/pnas.191044198

DO - 10.1073/pnas.191044198

M3 - Article

C2 - 11526211

AN - SCOPUS:0035845499

VL - 98

SP - 10966

EP - 10971

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 19

ER -