Predicting the onset of glaucoma: The confocal scanning laser ophthalmoscopy ancillary study to the ocular hypertension treatment study

Robert N. Weinreb, Linda M. Zangwill, Sonia Jain, Lida M. Becerra, Keri Dirkes, Jody R. Piltz-Seymour, George A. Cioffi, Gary L. Trick, Anne L. Coleman, James D Brandt, Jefferey M. Liebmann, Mae O. Gordon, Michael A. Kass

Research output: Contribution to journalArticle

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Abstract

Objective: To evaluate the predictive ability of baseline confocal scanning laser ophthalmoscopy (CSLO) Glaucoma Probability Score (GPS) for the development of primary open-angle glaucoma (POAG) and to compare it with the Moorfields regression analysis (MRA) classification, other topographic optic disc parameters, and stereophotograph-based cup-to-disc ratio. Design: Longitudinal, randomized clinical trial. Participants: We included 857 eyes of 438 participants in the CSLO Ancillary Study to the Ocular Hypertension Treatment Study (OHTS) with good quality baseline CSLO images. Methods: The ability of baseline GPS, MRA, and optic disc parameters to predict the development of POAG was evaluated in univariate and multivariable proportional hazard ratio analyses. Likelihood ratios and positive and negative predictive values were compared. Main Outcome Measures: The POAG end point as determined by repeatable changes in the visual field or optic disc. Results: Sixty-four eyes of 50 CSLO Ancillary Study participants developed POAG. Median time to reach a POAG end point was 72.3 months. The 93 eyes of 388 participants not reaching endpoint were followed for a median of 124.9 months. Baseline GPS identified many more eyes as outside normal limits than the MRA. In multivariable analyses, all regional and global baseline GPS indices were significantly associated with the development of POAG; hazard ratios (95% confidence interval) ranged from 2.92 to 3.74 for an outside normal limits result. The MRA indices were also significantly associated with the development of POAG in multivariable analyses. In addition, the predictive ability of baseline GPS, MRA and stereometric parameters were similar to the predictive ability of models using photograph-based horizontal cup-to-disc ratio. Conclusions: These results suggest that baseline GPS, MRA, and stereoparameters alone or when combined with baseline clinical and demographic factors can be used to predict the development of POAG end points in OHTS participants and are as effective as stereophotographs for estimating the risk of developing POAG in ocular hypertensive subjects. Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references.

Original languageEnglish (US)
Pages (from-to)1674-1683
Number of pages10
JournalOphthalmology
Volume117
Issue number9
DOIs
StatePublished - Sep 2010

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Ophthalmoscopy
Ocular Hypertension
Glaucoma
Lasers
Aptitude
Regression Analysis
Optic Disk
Disclosure
Primary Open Angle Glaucoma
Visual Fields
Randomized Controlled Trials
Demography
Outcome Assessment (Health Care)
Confidence Intervals

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Weinreb, R. N., Zangwill, L. M., Jain, S., Becerra, L. M., Dirkes, K., Piltz-Seymour, J. R., ... Kass, M. A. (2010). Predicting the onset of glaucoma: The confocal scanning laser ophthalmoscopy ancillary study to the ocular hypertension treatment study. Ophthalmology, 117(9), 1674-1683. https://doi.org/10.1016/j.ophtha.2010.03.044

Predicting the onset of glaucoma : The confocal scanning laser ophthalmoscopy ancillary study to the ocular hypertension treatment study. / Weinreb, Robert N.; Zangwill, Linda M.; Jain, Sonia; Becerra, Lida M.; Dirkes, Keri; Piltz-Seymour, Jody R.; Cioffi, George A.; Trick, Gary L.; Coleman, Anne L.; Brandt, James D; Liebmann, Jefferey M.; Gordon, Mae O.; Kass, Michael A.

In: Ophthalmology, Vol. 117, No. 9, 09.2010, p. 1674-1683.

Research output: Contribution to journalArticle

Weinreb, RN, Zangwill, LM, Jain, S, Becerra, LM, Dirkes, K, Piltz-Seymour, JR, Cioffi, GA, Trick, GL, Coleman, AL, Brandt, JD, Liebmann, JM, Gordon, MO & Kass, MA 2010, 'Predicting the onset of glaucoma: The confocal scanning laser ophthalmoscopy ancillary study to the ocular hypertension treatment study', Ophthalmology, vol. 117, no. 9, pp. 1674-1683. https://doi.org/10.1016/j.ophtha.2010.03.044
Weinreb, Robert N. ; Zangwill, Linda M. ; Jain, Sonia ; Becerra, Lida M. ; Dirkes, Keri ; Piltz-Seymour, Jody R. ; Cioffi, George A. ; Trick, Gary L. ; Coleman, Anne L. ; Brandt, James D ; Liebmann, Jefferey M. ; Gordon, Mae O. ; Kass, Michael A. / Predicting the onset of glaucoma : The confocal scanning laser ophthalmoscopy ancillary study to the ocular hypertension treatment study. In: Ophthalmology. 2010 ; Vol. 117, No. 9. pp. 1674-1683.
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AU - Becerra, Lida M.

AU - Dirkes, Keri

AU - Piltz-Seymour, Jody R.

AU - Cioffi, George A.

AU - Trick, Gary L.

AU - Coleman, Anne L.

AU - Brandt, James D

AU - Liebmann, Jefferey M.

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N2 - Objective: To evaluate the predictive ability of baseline confocal scanning laser ophthalmoscopy (CSLO) Glaucoma Probability Score (GPS) for the development of primary open-angle glaucoma (POAG) and to compare it with the Moorfields regression analysis (MRA) classification, other topographic optic disc parameters, and stereophotograph-based cup-to-disc ratio. Design: Longitudinal, randomized clinical trial. Participants: We included 857 eyes of 438 participants in the CSLO Ancillary Study to the Ocular Hypertension Treatment Study (OHTS) with good quality baseline CSLO images. Methods: The ability of baseline GPS, MRA, and optic disc parameters to predict the development of POAG was evaluated in univariate and multivariable proportional hazard ratio analyses. Likelihood ratios and positive and negative predictive values were compared. Main Outcome Measures: The POAG end point as determined by repeatable changes in the visual field or optic disc. Results: Sixty-four eyes of 50 CSLO Ancillary Study participants developed POAG. Median time to reach a POAG end point was 72.3 months. The 93 eyes of 388 participants not reaching endpoint were followed for a median of 124.9 months. Baseline GPS identified many more eyes as outside normal limits than the MRA. In multivariable analyses, all regional and global baseline GPS indices were significantly associated with the development of POAG; hazard ratios (95% confidence interval) ranged from 2.92 to 3.74 for an outside normal limits result. The MRA indices were also significantly associated with the development of POAG in multivariable analyses. In addition, the predictive ability of baseline GPS, MRA and stereometric parameters were similar to the predictive ability of models using photograph-based horizontal cup-to-disc ratio. Conclusions: These results suggest that baseline GPS, MRA, and stereoparameters alone or when combined with baseline clinical and demographic factors can be used to predict the development of POAG end points in OHTS participants and are as effective as stereophotographs for estimating the risk of developing POAG in ocular hypertensive subjects. Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references.

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