Predicting the emergence of tick-borne infections based on climatic changes in Korea

Joon Seok Chae, Jennifer Zipser Adjemian, Heung Chul Kim, Sungjin Ko, Terry A. Klein, Janet E Foley

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Granulocytic anaplasmosis (GA) and monocytic ehrlichiosis (ME) are maintained in wild rodent reservoirs and tick vectors in the Republic of Korea. This study investigated the prevalence of 2 tick-borne pathogens, Anaplasma phagocytophilum and Ehrlichia chaffeensis, in wild rodents and ticks in central Korea to identify any significant associations with existing or changing climatic conditions. Specifically, the goal of this study was to develop simple models for the probability of occurrence of an epidemic of GA or ME as a function of climate in an area in a given year. Climatic data from 2 regions, Munsan and Dongducheon, Gyeonggi, in central Korea (between the Demilitarized Zone and Seoul, latitude between 37°N-38°N and longitude between 127°E-128°E), were analyzed with respect to the prevalence of GA and ME in Paju, Yoncheon, Pocheon, and Dongducheon for the period from 2001 to 2005. Rates of A. phagocytophilum and E. chaffeensis decreased as the total yearly precipitation levels and daily humidity increased, and as the daily mean sunshine hours decreased. Rates of A. phagocytophilum and E. chaffeensis from rodent ticks and rodents increased in the fall season. Linear regression analyses evaluating the numbers of positive samples by sample type found that rodent ticks were 6.64 times more likely to be actively infected with A. phagocytophilum than grass ticks or rodents, though the likelihood of any samples testing positive for this pathogen decreased by 0.17 as the annual mean level of precipitation increased by 1 mm. For E. chaffeensis, rodents were 15.67 times more likely to be infected than ticks. Logistic regression analyses evaluating each sample separately found that the odds of infection with A. phagocytophilum were nearly 5 times greater for rodents than ticks. In these analyses, precipitation was one potential factor to account for the prevalence of tickborne diseases.

Original languageEnglish (US)
Pages (from-to)265-275
Number of pages11
JournalVector-Borne and Zoonotic Diseases
Volume8
Issue number2
DOIs
StatePublished - Apr 1 2008

Fingerprint

Tick-Borne Diseases
Ticks
Korea
Anaplasma phagocytophilum
Rodentia
Ehrlichia chaffeensis
Anaplasmosis
Ehrlichiosis
Regression Analysis
Republic of Korea
Sunlight
Humidity
Poaceae
Climate
Linear Models
Cross-Sectional Studies
Logistic Models

Keywords

  • Anaplasma phagocytophilum
  • Climate
  • Ehrlichia chaffeensis
  • PCR
  • Prediction
  • Tick-borne infections
  • Ticks
  • Wild rodents

ASJC Scopus subject areas

  • Infectious Diseases
  • Parasitology

Cite this

Predicting the emergence of tick-borne infections based on climatic changes in Korea. / Chae, Joon Seok; Adjemian, Jennifer Zipser; Kim, Heung Chul; Ko, Sungjin; Klein, Terry A.; Foley, Janet E.

In: Vector-Borne and Zoonotic Diseases, Vol. 8, No. 2, 01.04.2008, p. 265-275.

Research output: Contribution to journalArticle

Chae, Joon Seok ; Adjemian, Jennifer Zipser ; Kim, Heung Chul ; Ko, Sungjin ; Klein, Terry A. ; Foley, Janet E. / Predicting the emergence of tick-borne infections based on climatic changes in Korea. In: Vector-Borne and Zoonotic Diseases. 2008 ; Vol. 8, No. 2. pp. 265-275.
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AB - Granulocytic anaplasmosis (GA) and monocytic ehrlichiosis (ME) are maintained in wild rodent reservoirs and tick vectors in the Republic of Korea. This study investigated the prevalence of 2 tick-borne pathogens, Anaplasma phagocytophilum and Ehrlichia chaffeensis, in wild rodents and ticks in central Korea to identify any significant associations with existing or changing climatic conditions. Specifically, the goal of this study was to develop simple models for the probability of occurrence of an epidemic of GA or ME as a function of climate in an area in a given year. Climatic data from 2 regions, Munsan and Dongducheon, Gyeonggi, in central Korea (between the Demilitarized Zone and Seoul, latitude between 37°N-38°N and longitude between 127°E-128°E), were analyzed with respect to the prevalence of GA and ME in Paju, Yoncheon, Pocheon, and Dongducheon for the period from 2001 to 2005. Rates of A. phagocytophilum and E. chaffeensis decreased as the total yearly precipitation levels and daily humidity increased, and as the daily mean sunshine hours decreased. Rates of A. phagocytophilum and E. chaffeensis from rodent ticks and rodents increased in the fall season. Linear regression analyses evaluating the numbers of positive samples by sample type found that rodent ticks were 6.64 times more likely to be actively infected with A. phagocytophilum than grass ticks or rodents, though the likelihood of any samples testing positive for this pathogen decreased by 0.17 as the annual mean level of precipitation increased by 1 mm. For E. chaffeensis, rodents were 15.67 times more likely to be infected than ticks. Logistic regression analyses evaluating each sample separately found that the odds of infection with A. phagocytophilum were nearly 5 times greater for rodents than ticks. In these analyses, precipitation was one potential factor to account for the prevalence of tickborne diseases.

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