Abstract
OBJECTIVE: To assess ovarian follicular development and ovulation rates in women starting to take oral contraceptives (OC) on menstrual cycle day 1, 4, or 7. METHODS: One hundred thirty women starting treatment with OC were randomized to begin use of ethinyl estradiol, 30 μg, plus norgestrel, 300 μg, on menstrual cycle day 1 (group 1), 4 (group 2), or 7 (group 3). Follicular development was assessed by vaginal ultrasonography on menstrual cycle days 7, 14, 21, and 28, and serum progesterone levels were measured on menstrual cycle days 21 and 28. At a .05 level of significance (two-tailed) and power of 80%, 84 participants were required to complete the study. Eighty-five women who met study criteria, made minimal dosing errors, and underwent at least three ultrasonographic examinations were analyzed. RESULTS: A follicle-like structure that reached a maximum diameter over 13 mm was observed in three of 29 (10.3%), five of 29 (17.2%), and 12 of 27 (44.4%) women in groups 1, 2 and 3, respectively (P = 0.003). The median maximum follicle size for each group was 9.0 mm, 9.0 mm, and 12.0 mm for start day 1, 4, and 7 respectively (P < .001). Evidence of ovulation based on serum progesterone was present in two, one, and zero women in groups 1, 2, and 3, respectively (P = .2). CONCLUSION: Although a delay in oral contraceptive initiation results in significantly more ovarian follicular development, the postponement does not appear to increase actual ovulation rates.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 177-182 |
| Number of pages | 6 |
| Journal | Obstetrics and Gynecology |
| Volume | 99 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2002 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Obstetrics and Gynecology
Cite this
Predicting risk of ovulation in new start oral contraceptive users. / Schwartz, Jill L.; Creinin, Mitchell D; Pymar, Helen C.; Reid, Lynn.
In: Obstetrics and Gynecology, Vol. 99, No. 2, 2002, p. 177-182.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Predicting risk of ovulation in new start oral contraceptive users
AU - Schwartz, Jill L.
AU - Creinin, Mitchell D
AU - Pymar, Helen C.
AU - Reid, Lynn
PY - 2002
Y1 - 2002
N2 - OBJECTIVE: To assess ovarian follicular development and ovulation rates in women starting to take oral contraceptives (OC) on menstrual cycle day 1, 4, or 7. METHODS: One hundred thirty women starting treatment with OC were randomized to begin use of ethinyl estradiol, 30 μg, plus norgestrel, 300 μg, on menstrual cycle day 1 (group 1), 4 (group 2), or 7 (group 3). Follicular development was assessed by vaginal ultrasonography on menstrual cycle days 7, 14, 21, and 28, and serum progesterone levels were measured on menstrual cycle days 21 and 28. At a .05 level of significance (two-tailed) and power of 80%, 84 participants were required to complete the study. Eighty-five women who met study criteria, made minimal dosing errors, and underwent at least three ultrasonographic examinations were analyzed. RESULTS: A follicle-like structure that reached a maximum diameter over 13 mm was observed in three of 29 (10.3%), five of 29 (17.2%), and 12 of 27 (44.4%) women in groups 1, 2 and 3, respectively (P = 0.003). The median maximum follicle size for each group was 9.0 mm, 9.0 mm, and 12.0 mm for start day 1, 4, and 7 respectively (P < .001). Evidence of ovulation based on serum progesterone was present in two, one, and zero women in groups 1, 2, and 3, respectively (P = .2). CONCLUSION: Although a delay in oral contraceptive initiation results in significantly more ovarian follicular development, the postponement does not appear to increase actual ovulation rates.
AB - OBJECTIVE: To assess ovarian follicular development and ovulation rates in women starting to take oral contraceptives (OC) on menstrual cycle day 1, 4, or 7. METHODS: One hundred thirty women starting treatment with OC were randomized to begin use of ethinyl estradiol, 30 μg, plus norgestrel, 300 μg, on menstrual cycle day 1 (group 1), 4 (group 2), or 7 (group 3). Follicular development was assessed by vaginal ultrasonography on menstrual cycle days 7, 14, 21, and 28, and serum progesterone levels were measured on menstrual cycle days 21 and 28. At a .05 level of significance (two-tailed) and power of 80%, 84 participants were required to complete the study. Eighty-five women who met study criteria, made minimal dosing errors, and underwent at least three ultrasonographic examinations were analyzed. RESULTS: A follicle-like structure that reached a maximum diameter over 13 mm was observed in three of 29 (10.3%), five of 29 (17.2%), and 12 of 27 (44.4%) women in groups 1, 2 and 3, respectively (P = 0.003). The median maximum follicle size for each group was 9.0 mm, 9.0 mm, and 12.0 mm for start day 1, 4, and 7 respectively (P < .001). Evidence of ovulation based on serum progesterone was present in two, one, and zero women in groups 1, 2, and 3, respectively (P = .2). CONCLUSION: Although a delay in oral contraceptive initiation results in significantly more ovarian follicular development, the postponement does not appear to increase actual ovulation rates.
UR - http://www.scopus.com/inward/record.url?scp=0036152905&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036152905&partnerID=8YFLogxK
U2 - 10.1016/S0029-7844(01)01676-3
DO - 10.1016/S0029-7844(01)01676-3
M3 - Article
C2 - 11814492
AN - SCOPUS:0036152905
VL - 99
SP - 177
EP - 182
JO - Obstetrics and Gynecology
JF - Obstetrics and Gynecology
SN - 0029-7844
IS - 2
ER -