Abstract
Objective: To develop a late-life dementia risk index that can accurately stratify older adults into those with a low, moderate, or high risk of developing dementia within 6 years. Methods: Subjects were 3,375 participants in the Cardiovascular Health Cognition Study without evidence of dementia at baseline. We used logistic regression to identify those factors most predictive of developing incident dementia within 6 years and developed a point system based on the logistic regression coefficients. Results: Subjects had a mean age of 76 years at baseline; 59% were women and 15% were African American. Fourteen percent (n = 480) developed dementia within 6 years. The final latelife dementia risk index included older age (1-2 points), poor cognitive test performance (2-4 points), body mass index <18.5 (2 points), ≥1 apolipoprotein E ε4 alleles (1 point), cerebral MRI findings of white matter disease (1 point) or ventricular enlargement (1 point), internal carotid artery thickening on ultrasound (1 point), history of bypass surgery (1 point), slow physical performance (1 point), and lack of alcohol consumption (1 point) (c statistic, 0.81; 95% confidence interval, 0.79-0.83). Four percent of subjects with low scores developed dementia over 6 years compared with 23% of subjects with moderate scores and 56% of subjects with high scores. Conclusions: The late-life dementia risk index accurately stratified older adults into those with low, moderate, and high risk of developing dementia. This tool could be used in clinical or research settings to target prevention and intervention strategies toward high-risk individuals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 173-179 |
| Number of pages | 7 |
| Journal | Neurology |
| Volume | 73 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jul 21 2009 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Clinical Neurology
Cite this
Predicting risk of dementia in older adults : The late-life dementia risk index. / Barnes, D. E.; Covinsky, K. E.; Whitmer, Rachel; Kuller, L. H.; Lopez, O. L.; Yaffe, K.
In: Neurology, Vol. 73, No. 3, 21.07.2009, p. 173-179.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Predicting risk of dementia in older adults
T2 - The late-life dementia risk index
AU - Barnes, D. E.
AU - Covinsky, K. E.
AU - Whitmer, Rachel
AU - Kuller, L. H.
AU - Lopez, O. L.
AU - Yaffe, K.
PY - 2009/7/21
Y1 - 2009/7/21
N2 - Objective: To develop a late-life dementia risk index that can accurately stratify older adults into those with a low, moderate, or high risk of developing dementia within 6 years. Methods: Subjects were 3,375 participants in the Cardiovascular Health Cognition Study without evidence of dementia at baseline. We used logistic regression to identify those factors most predictive of developing incident dementia within 6 years and developed a point system based on the logistic regression coefficients. Results: Subjects had a mean age of 76 years at baseline; 59% were women and 15% were African American. Fourteen percent (n = 480) developed dementia within 6 years. The final latelife dementia risk index included older age (1-2 points), poor cognitive test performance (2-4 points), body mass index <18.5 (2 points), ≥1 apolipoprotein E ε4 alleles (1 point), cerebral MRI findings of white matter disease (1 point) or ventricular enlargement (1 point), internal carotid artery thickening on ultrasound (1 point), history of bypass surgery (1 point), slow physical performance (1 point), and lack of alcohol consumption (1 point) (c statistic, 0.81; 95% confidence interval, 0.79-0.83). Four percent of subjects with low scores developed dementia over 6 years compared with 23% of subjects with moderate scores and 56% of subjects with high scores. Conclusions: The late-life dementia risk index accurately stratified older adults into those with low, moderate, and high risk of developing dementia. This tool could be used in clinical or research settings to target prevention and intervention strategies toward high-risk individuals.
AB - Objective: To develop a late-life dementia risk index that can accurately stratify older adults into those with a low, moderate, or high risk of developing dementia within 6 years. Methods: Subjects were 3,375 participants in the Cardiovascular Health Cognition Study without evidence of dementia at baseline. We used logistic regression to identify those factors most predictive of developing incident dementia within 6 years and developed a point system based on the logistic regression coefficients. Results: Subjects had a mean age of 76 years at baseline; 59% were women and 15% were African American. Fourteen percent (n = 480) developed dementia within 6 years. The final latelife dementia risk index included older age (1-2 points), poor cognitive test performance (2-4 points), body mass index <18.5 (2 points), ≥1 apolipoprotein E ε4 alleles (1 point), cerebral MRI findings of white matter disease (1 point) or ventricular enlargement (1 point), internal carotid artery thickening on ultrasound (1 point), history of bypass surgery (1 point), slow physical performance (1 point), and lack of alcohol consumption (1 point) (c statistic, 0.81; 95% confidence interval, 0.79-0.83). Four percent of subjects with low scores developed dementia over 6 years compared with 23% of subjects with moderate scores and 56% of subjects with high scores. Conclusions: The late-life dementia risk index accurately stratified older adults into those with low, moderate, and high risk of developing dementia. This tool could be used in clinical or research settings to target prevention and intervention strategies toward high-risk individuals.
UR - http://www.scopus.com/inward/record.url?scp=68949173751&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=68949173751&partnerID=8YFLogxK
U2 - 10.1212/WNL.0b013e3181a81636
DO - 10.1212/WNL.0b013e3181a81636
M3 - Article
C2 - 19439724
AN - SCOPUS:68949173751
VL - 73
SP - 173
EP - 179
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 3
ER -