TY - JOUR
T1 - Predicting Mechanical Failure Following Cervical Deformity Surgery
T2 - A Composite Score Integrating Age-Adjusted Cervical Alignment Targets
AU - On behalf of the International Spine Study Group (ISSG)
AU - Lafage, Renaud
AU - Smith, Justin S.
AU - Soroceanu, Alexandra
AU - Ames, Christopher
AU - Passias, Peter
AU - Shaffrey, Christopher
AU - Mundis, Gregory
AU - Alshabab, Basel Sheikh
AU - Protopsaltis, Themistocles
AU - Klineberg, Eric
AU - Elysee, Jonathan
AU - Kim, Han Jo
AU - Bess, Shay
AU - Schwab, Frank
AU - Lafage, Virginie
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by The International Spine Study Group (ISSG) is funded through research grants from DePuy Synthes (current), Nuvasive (current), K2M (current), Innovasis (past), Biomet (past), and individual donations.
Publisher Copyright:
© The Author(s) 2022.
PY - 2022
Y1 - 2022
N2 - Study Design: Retrospective cohort study. Objectives: Investigate a composite score to evaluate the relationship between alignment proportionality and risk of distal junctional kyphosis (DJK). Methods: 84 patients with minimum 1 year follow-up were included (age = 61.1 ± 10.3 years, 64.3% women). The Cervical Score was constructed using offsets from age-adjusted normative values for sagittal vertical axis (SVA), T1 Slope (TS), and TS minus cervical lordosis (CL). Individual points were assigned based on offset with age-adjusted alignment targets and summed to generate the Cervical Score. Rates of mechanical failure (DJK revision or severe DJK [DJK> 20° and ΔDJK> 10°]) were assessed overall and based on Cervical Score. Logistical regressions assessed associations between early radiographic alignment and 1-year failure rate. Results: Mechanical failure rate was 21.4% (N = 18), 10.7% requiring revision. By multivariate logistical regression: 3-month T1S (OR:.935), TS-CL (OR:0.882), and SVA (OR:1.015) were independent predictors of 1-year failure (all P <.05). Cervical Score ranged (−6 to 6), 37.8% of patients between −1 and 1, and 50.0% with 2 or higher. DJK patients had significantly higher Cervical Score (4.1 ± 1.3 vs.6 ± 2.2, P <.001). Patients with a score ≥3 were significantly more likely to develop a failure (71.4%) with OR of 38.55 (95%CI [7.73; 192.26]) and Nagelkerke r2.524 (P <.001) Conclusion: This study developed a composite alignment score predictive of mechanical failures in CD surgery. A score ≥3 at 3 months following surgery was associated with a marked increase in failure rate. The Cervical Score can be used to analyze sagittal alignment and help define realignment objectives to reduce mechanical failure.
AB - Study Design: Retrospective cohort study. Objectives: Investigate a composite score to evaluate the relationship between alignment proportionality and risk of distal junctional kyphosis (DJK). Methods: 84 patients with minimum 1 year follow-up were included (age = 61.1 ± 10.3 years, 64.3% women). The Cervical Score was constructed using offsets from age-adjusted normative values for sagittal vertical axis (SVA), T1 Slope (TS), and TS minus cervical lordosis (CL). Individual points were assigned based on offset with age-adjusted alignment targets and summed to generate the Cervical Score. Rates of mechanical failure (DJK revision or severe DJK [DJK> 20° and ΔDJK> 10°]) were assessed overall and based on Cervical Score. Logistical regressions assessed associations between early radiographic alignment and 1-year failure rate. Results: Mechanical failure rate was 21.4% (N = 18), 10.7% requiring revision. By multivariate logistical regression: 3-month T1S (OR:.935), TS-CL (OR:0.882), and SVA (OR:1.015) were independent predictors of 1-year failure (all P <.05). Cervical Score ranged (−6 to 6), 37.8% of patients between −1 and 1, and 50.0% with 2 or higher. DJK patients had significantly higher Cervical Score (4.1 ± 1.3 vs.6 ± 2.2, P <.001). Patients with a score ≥3 were significantly more likely to develop a failure (71.4%) with OR of 38.55 (95%CI [7.73; 192.26]) and Nagelkerke r2.524 (P <.001) Conclusion: This study developed a composite alignment score predictive of mechanical failures in CD surgery. A score ≥3 at 3 months following surgery was associated with a marked increase in failure rate. The Cervical Score can be used to analyze sagittal alignment and help define realignment objectives to reduce mechanical failure.
KW - CD
KW - cervical deformity
KW - distal junctional kyphosis
KW - DJK
KW - mechanical failure
KW - sagittal alignment
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U2 - 10.1177/21925682221086535
DO - 10.1177/21925682221086535
M3 - Article
AN - SCOPUS:85128242605
JO - Global Spine Journal
JF - Global Spine Journal
SN - 2192-5682
ER -