Predicting compensation voltage for singly-charged ions in high-field asymmetric waveform ion mobility spectrometry (FAIMS)

Alexander A. Aksenov, James Kapron, Cristina E Davis

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Correlation between compensation voltage (CV) and the m/z ratio of singly-charged ions was elucidated. The experimental data for various alkylammonium homologues and various pharmaceutical compounds were used to construct empirical calibration curves that were fit using commercial regression analysis software packages. The best fit equations were applied to calculate the CV differences (ΔCV) in pure N2 and N2/He 50/50 carrier gasses and CV values for a variety of compounds using only m/z values. The calculated values were in good agreement with experimental data and ΔCV values exhibited a very strong correlation with m/z. Application of these empirical calculations may provide a powerful CV prediction tool for researchers using high-field asymmetric waveform ion mobility spectrometry (FAIMS) and increase the value of FAIMS as an analytical method.

Original languageEnglish (US)
Pages (from-to)1794-1798
Number of pages5
JournalJournal of the American Society for Mass Spectrometry
Volume23
Issue number10
DOIs
StatePublished - Oct 2012

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Keywords

  • Compensation voltage (CV)
  • Differential mobility spectrometry (DMS)
  • High field asymmetric waveform ion mobility spectrometry (FAIMS)
  • Mass to charge ratio (m/z)
  • Mathematical prediction models

ASJC Scopus subject areas

  • Structural Biology
  • Spectroscopy

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