Preconcentration and analysis of trace volatile carbonyl compounds

Mingxiao Li, Souvik Biswas, Michael H. Nantz, Richard M. Higashi, Xiao An Fu

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

We describe a preconcentration device that may be suitable for quantitative analysis of trace volatile ketones and aldehydes in ambient air as well as in human breath. The approach is based on microreactor chips fabricated from silicon wafers. The microreactors have thousands of micropillars in microfluidic channels for uniformly distributing a gaseous sample flowing through the chips. The surfaces of the micropillars are functionalized with a quaternary ammonium aminooxy salt, [2-(aminooxy)ethyl]-N,N,N-trimethylammonium iodide (ATM), for trapping trace ketones and aldehydes by means of oximation reactions. ATM adducts and unreacted ATM are eluted from the microreactor with less than 40 μL of methanol and directly analyzed by nanospray Fourier transform ion cyclotron resonance (FTICR) mass spectrometry (MS). Ketones and aldehydes at levels of 1 ppbv have been detected using this microreactor and FTICR-MS system.

Original languageEnglish (US)
Pages (from-to)1288-1293
Number of pages6
JournalAnalytical Chemistry
Volume84
Issue number3
DOIs
StatePublished - Feb 7 2012
Externally publishedYes

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Carbonyl compounds
Automatic teller machines
Ketones
Aldehydes
Cyclotron resonance
Mass spectrometry
Fourier transforms
Ions
Iodides
Silicon wafers
Ammonium Compounds
Microfluidics
Methanol
Salts
Air
Chemical analysis

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Li, M., Biswas, S., Nantz, M. H., Higashi, R. M., & Fu, X. A. (2012). Preconcentration and analysis of trace volatile carbonyl compounds. Analytical Chemistry, 84(3), 1288-1293. https://doi.org/10.1021/ac2021757

Preconcentration and analysis of trace volatile carbonyl compounds. / Li, Mingxiao; Biswas, Souvik; Nantz, Michael H.; Higashi, Richard M.; Fu, Xiao An.

In: Analytical Chemistry, Vol. 84, No. 3, 07.02.2012, p. 1288-1293.

Research output: Contribution to journalArticle

Li, M, Biswas, S, Nantz, MH, Higashi, RM & Fu, XA 2012, 'Preconcentration and analysis of trace volatile carbonyl compounds', Analytical Chemistry, vol. 84, no. 3, pp. 1288-1293. https://doi.org/10.1021/ac2021757
Li, Mingxiao ; Biswas, Souvik ; Nantz, Michael H. ; Higashi, Richard M. ; Fu, Xiao An. / Preconcentration and analysis of trace volatile carbonyl compounds. In: Analytical Chemistry. 2012 ; Vol. 84, No. 3. pp. 1288-1293.
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