Precocious puberty

E. Kirk Neely, Stephanie Crossen

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

Purpose of review: Precocious puberty continues to elicit great interest and concern among medical practitioners, as well as the public. Recent findings: Studies have elucidated neural regulation of puberty by kisspeptin, neurokinin B, and other factors. Cohort studies from the North America and Europe suggest that the age of thelarche may be earlier than determined 2 decades ago, and menarche may be slightly earlier, but the causes are unclear. Long-term outcomes of gonadotropin-releasing hormone analog therapy demonstrate increases in final height in the youngest treated patients, with no apparent adverse bone or reproductive consequences. Summary: Although the appropriate threshold age of onset of central puberty remains uncertain, gonadotropinreleasing hormone analog therapy is well tolerated and effective in suppressing luteinizing hormone pulses and ovarian activity.

Original languageEnglish (US)
Pages (from-to)332-338
Number of pages7
JournalCurrent Opinion in Obstetrics and Gynecology
Volume26
Issue number5
DOIs
StatePublished - Oct 1 2014
Externally publishedYes

Keywords

  • Gonadotropin-releasing hormone
  • Histrelin
  • Leuprolide
  • Precocious puberty
  • Thelarche

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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