Preclinical Models of Ovarian Cancer: Pathogenesis, Problems, and Implications for Prevention

Anthony Karnezis, Kathleen R. Cho

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Preclinical models are relatively underutilized and underfunded resources for modeling the pathogenesis and prevention of ovarian cancers. Several reviews have detailed the numerous published models of ovarian cancer. In this review, we will provide an overview of experimental model systems, their strengths and limitations, and use selected models to illustrate how they can be used to address specific issues about ovarian cancer pathogenesis. We will then highlight some of the preclinical prevention studies performed to date and discuss experiments needed to address important unanswered questions about ovarian cancer prevention strategies.

Original languageEnglish (US)
Pages (from-to)789-800
Number of pages12
JournalClinical Obstetrics and Gynecology
Volume60
Issue number4
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Keywords

  • fallopian tube
  • laying hen
  • mouse model
  • ovarian cancer
  • ovary
  • prevention

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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