Preclinical imaging of mammary intraepithelial neoplasia with positron emission tomography

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Small-animal imaging with positron emission tomography (PET) has become a valuable tool for evaluating preclinical models of breast cancer and other diseases. In this review, we examine a number of issues related to preclinical imaging studies with PET, using transgenic models of ductal carcinoma in situ and metastasis as specific examples. We discuss imaging components such as reconstruction, normalization, and extraction of quantitative parameters. We also analyze the effect of longitudinal correlations on cohort size and present some simple statistical techniques for determining cohort sizes that may be helpful in designing preclinical imaging studies. We describe studies that are greatly facilitated by access to non-invasive imaging data including a study involving multiple endpoints and another investigating metastasis. We conclude with a brief survey of emerging approaches in small-animal PET imaging.

Original languageEnglish (US)
Pages (from-to)137-149
Number of pages13
JournalJournal of Mammary Gland Biology and Neoplasia
Volume11
Issue number2
DOIs
StatePublished - Apr 2006

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Positron-Emission Tomography
Breast
Neoplasm Metastasis
Neoplasms
Carcinoma, Intraductal, Noninfiltrating
Breast Neoplasms
Surveys and Questionnaires

Keywords

  • Mammary intraepithelial neoplasia
  • Positron emission tomography
  • Preclinical imaging
  • Therapeutic response

ASJC Scopus subject areas

  • Cancer Research

Cite this

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abstract = "Small-animal imaging with positron emission tomography (PET) has become a valuable tool for evaluating preclinical models of breast cancer and other diseases. In this review, we examine a number of issues related to preclinical imaging studies with PET, using transgenic models of ductal carcinoma in situ and metastasis as specific examples. We discuss imaging components such as reconstruction, normalization, and extraction of quantitative parameters. We also analyze the effect of longitudinal correlations on cohort size and present some simple statistical techniques for determining cohort sizes that may be helpful in designing preclinical imaging studies. We describe studies that are greatly facilitated by access to non-invasive imaging data including a study involving multiple endpoints and another investigating metastasis. We conclude with a brief survey of emerging approaches in small-animal PET imaging.",
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AU - Borowsky, Alexander D

AU - Gregg, Jeffrey

AU - Cardiff, Robert

AU - Cherry, Simon R

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AB - Small-animal imaging with positron emission tomography (PET) has become a valuable tool for evaluating preclinical models of breast cancer and other diseases. In this review, we examine a number of issues related to preclinical imaging studies with PET, using transgenic models of ductal carcinoma in situ and metastasis as specific examples. We discuss imaging components such as reconstruction, normalization, and extraction of quantitative parameters. We also analyze the effect of longitudinal correlations on cohort size and present some simple statistical techniques for determining cohort sizes that may be helpful in designing preclinical imaging studies. We describe studies that are greatly facilitated by access to non-invasive imaging data including a study involving multiple endpoints and another investigating metastasis. We conclude with a brief survey of emerging approaches in small-animal PET imaging.

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