Precisely correlated firing in cells of the lateral geniculate nucleus

J. M. Alonso, William Martin Usrey, R. C. Reid

Research output: Contribution to journalArticle

340 Citations (Scopus)

Abstract

SIMPLE cells within layer IV of the cat primary visual cortex are selective for lines of a specific orientation. It has been proposed that their receptive-field properties are established by the pattern of connections that they receive from the lateral geniculate nucleus (LGN) of the thalamus. Thalamic inputs, however, represent only a small proportion of the synopses made onto simple cells, and others have argued that corticocortical connections are likely to be important in shaping simple- cell response properties. Here we describe a mechanism that might be involved in selectively strengthening the effect of thalamic inputs. We show that neighbouring geniculate neurons with overlapping receptive fields of the same type (on-centre or off-centre) often fire spikes that ace synchronized to within 1 millisecond. Moreover, these neurons often project to a common cortical target neuron where synchronous spikes are more effective in evoking a postsynaptic response. We propose that precisely correlated firing within a group of geniculate neurons could serve to reinforce the thalamic input to cortical simple cells.

Original languageEnglish (US)
Pages (from-to)815-819
Number of pages5
JournalNature
Volume383
Issue number6603
DOIs
StatePublished - 1996
Externally publishedYes

Fingerprint

Geniculate Bodies
Neurons
Lateral Thalamic Nuclei
Visual Cortex
Cats

ASJC Scopus subject areas

  • General

Cite this

Alonso, J. M., Usrey, W. M., & Reid, R. C. (1996). Precisely correlated firing in cells of the lateral geniculate nucleus. Nature, 383(6603), 815-819. https://doi.org/10.1038/383815a0

Precisely correlated firing in cells of the lateral geniculate nucleus. / Alonso, J. M.; Usrey, William Martin; Reid, R. C.

In: Nature, Vol. 383, No. 6603, 1996, p. 815-819.

Research output: Contribution to journalArticle

Alonso, JM, Usrey, WM & Reid, RC 1996, 'Precisely correlated firing in cells of the lateral geniculate nucleus', Nature, vol. 383, no. 6603, pp. 815-819. https://doi.org/10.1038/383815a0
Alonso, J. M. ; Usrey, William Martin ; Reid, R. C. / Precisely correlated firing in cells of the lateral geniculate nucleus. In: Nature. 1996 ; Vol. 383, No. 6603. pp. 815-819.
@article{1209f54df873468488e4856cde489edf,
title = "Precisely correlated firing in cells of the lateral geniculate nucleus",
abstract = "SIMPLE cells within layer IV of the cat primary visual cortex are selective for lines of a specific orientation. It has been proposed that their receptive-field properties are established by the pattern of connections that they receive from the lateral geniculate nucleus (LGN) of the thalamus. Thalamic inputs, however, represent only a small proportion of the synopses made onto simple cells, and others have argued that corticocortical connections are likely to be important in shaping simple- cell response properties. Here we describe a mechanism that might be involved in selectively strengthening the effect of thalamic inputs. We show that neighbouring geniculate neurons with overlapping receptive fields of the same type (on-centre or off-centre) often fire spikes that ace synchronized to within 1 millisecond. Moreover, these neurons often project to a common cortical target neuron where synchronous spikes are more effective in evoking a postsynaptic response. We propose that precisely correlated firing within a group of geniculate neurons could serve to reinforce the thalamic input to cortical simple cells.",
author = "Alonso, {J. M.} and Usrey, {William Martin} and Reid, {R. C.}",
year = "1996",
doi = "10.1038/383815a0",
language = "English (US)",
volume = "383",
pages = "815--819",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "6603",

}

TY - JOUR

T1 - Precisely correlated firing in cells of the lateral geniculate nucleus

AU - Alonso, J. M.

AU - Usrey, William Martin

AU - Reid, R. C.

PY - 1996

Y1 - 1996

N2 - SIMPLE cells within layer IV of the cat primary visual cortex are selective for lines of a specific orientation. It has been proposed that their receptive-field properties are established by the pattern of connections that they receive from the lateral geniculate nucleus (LGN) of the thalamus. Thalamic inputs, however, represent only a small proportion of the synopses made onto simple cells, and others have argued that corticocortical connections are likely to be important in shaping simple- cell response properties. Here we describe a mechanism that might be involved in selectively strengthening the effect of thalamic inputs. We show that neighbouring geniculate neurons with overlapping receptive fields of the same type (on-centre or off-centre) often fire spikes that ace synchronized to within 1 millisecond. Moreover, these neurons often project to a common cortical target neuron where synchronous spikes are more effective in evoking a postsynaptic response. We propose that precisely correlated firing within a group of geniculate neurons could serve to reinforce the thalamic input to cortical simple cells.

AB - SIMPLE cells within layer IV of the cat primary visual cortex are selective for lines of a specific orientation. It has been proposed that their receptive-field properties are established by the pattern of connections that they receive from the lateral geniculate nucleus (LGN) of the thalamus. Thalamic inputs, however, represent only a small proportion of the synopses made onto simple cells, and others have argued that corticocortical connections are likely to be important in shaping simple- cell response properties. Here we describe a mechanism that might be involved in selectively strengthening the effect of thalamic inputs. We show that neighbouring geniculate neurons with overlapping receptive fields of the same type (on-centre or off-centre) often fire spikes that ace synchronized to within 1 millisecond. Moreover, these neurons often project to a common cortical target neuron where synchronous spikes are more effective in evoking a postsynaptic response. We propose that precisely correlated firing within a group of geniculate neurons could serve to reinforce the thalamic input to cortical simple cells.

UR - http://www.scopus.com/inward/record.url?scp=0029852771&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029852771&partnerID=8YFLogxK

U2 - 10.1038/383815a0

DO - 10.1038/383815a0

M3 - Article

C2 - 8893005

AN - SCOPUS:0029852771

VL - 383

SP - 815

EP - 819

JO - Nature

JF - Nature

SN - 0028-0836

IS - 6603

ER -