Precisely correlated firing in cells of the lateral geniculate nucleus

J. M. Alonso, William Martin Usrey, R. C. Reid

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343 Scopus citations

Abstract

SIMPLE cells within layer IV of the cat primary visual cortex are selective for lines of a specific orientation. It has been proposed that their receptive-field properties are established by the pattern of connections that they receive from the lateral geniculate nucleus (LGN) of the thalamus. Thalamic inputs, however, represent only a small proportion of the synopses made onto simple cells, and others have argued that corticocortical connections are likely to be important in shaping simple- cell response properties. Here we describe a mechanism that might be involved in selectively strengthening the effect of thalamic inputs. We show that neighbouring geniculate neurons with overlapping receptive fields of the same type (on-centre or off-centre) often fire spikes that ace synchronized to within 1 millisecond. Moreover, these neurons often project to a common cortical target neuron where synchronous spikes are more effective in evoking a postsynaptic response. We propose that precisely correlated firing within a group of geniculate neurons could serve to reinforce the thalamic input to cortical simple cells.

Original languageEnglish (US)
Pages (from-to)815-819
Number of pages5
JournalNature
Volume383
Issue number6603
DOIs
StatePublished - 1996
Externally publishedYes

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    Alonso, J. M., Usrey, W. M., & Reid, R. C. (1996). Precisely correlated firing in cells of the lateral geniculate nucleus. Nature, 383(6603), 815-819. https://doi.org/10.1038/383815a0