Prealbumin is associated with visceral fat mass in patients receiving hemodialysis

Alessio Molfino, Steven B. Heymsfield, Fansan Zhu, Peter Kotanko, Nathan W. Levin, Tjien Dwyer, George Kaysen

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: Albumin and prealbumin are associated with nutritional status and inflammatory status. Each has a residual effect on mortality outcomes when included in regression models that include the other. Prealbumin is increased in the obese mouse model as a consequence of stabilization of prealbumin by retinol binding protein 4 (RBP4) secreted by adipocytes. We carried out this study to establish the contribution of adiposity to prealbumin levels in prevalent patients receiving dialysis and the relationship of prealbumin to RBP4. Design and Methods: We determined whether prealbumin was associated with adiposity in patients receiving hemodialysis (HD), controlling for the effects of inflammation and nutrition. We evaluated body composition in 48 prevalent patients receiving HD by magnetic resonance imaging (MRI), measuring total skeletal muscle mass (SM), visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and serum albumin, prealbumin, RBP4, and interleukin-6 (IL-6) levels. We used normalized protein catabolic rate (nPCR) to report nutrition and separately analyzed the determinants of albumin and then of prealbumin by multiple stepwise regression. Results: Thirty-two patients were women, 16 patients were diabetic, and median age and body mass index were 54.5 and 27.3 kg/m2, respectively. Median total adipose tissue (TAT) was 24.3 kg and VAT was 3.25 kg. Prealbumin was positively associated with VAT, nPCR, and RBP4 and was negatively associated with IL-6; r2 for the model was 0.64. By contrast, albumin was positively associated with nPCR and negatively associated with IL-6 but not with any measure of adiposity (r2 for the model=0.2). Conclusions: Prealbumin, like albumin, is associated with markers of nutrition (nPCR) and inflammation, but unlike albumin, prealbumin levels are positively associated with visceral adiposity.

Original languageEnglish (US)
Pages (from-to)406-410
Number of pages5
JournalJournal of Renal Nutrition
Volume23
Issue number6
DOIs
StatePublished - Nov 2013

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Prealbumin
Intra-Abdominal Fat
Renal Dialysis
Retinol-Binding Proteins
Adiposity
Albumins
Interleukin-6
Proteins
Inflammation
Obese Mice
Subcutaneous Fat
Body Composition
Nutritional Status
Adipocytes
Serum Albumin
Adipose Tissue
Dialysis
Skeletal Muscle
Body Mass Index
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Nephrology

Cite this

Prealbumin is associated with visceral fat mass in patients receiving hemodialysis. / Molfino, Alessio; Heymsfield, Steven B.; Zhu, Fansan; Kotanko, Peter; Levin, Nathan W.; Dwyer, Tjien; Kaysen, George.

In: Journal of Renal Nutrition, Vol. 23, No. 6, 11.2013, p. 406-410.

Research output: Contribution to journalArticle

Molfino, A, Heymsfield, SB, Zhu, F, Kotanko, P, Levin, NW, Dwyer, T & Kaysen, G 2013, 'Prealbumin is associated with visceral fat mass in patients receiving hemodialysis', Journal of Renal Nutrition, vol. 23, no. 6, pp. 406-410. https://doi.org/10.1053/j.jrn.2013.02.007
Molfino, Alessio ; Heymsfield, Steven B. ; Zhu, Fansan ; Kotanko, Peter ; Levin, Nathan W. ; Dwyer, Tjien ; Kaysen, George. / Prealbumin is associated with visceral fat mass in patients receiving hemodialysis. In: Journal of Renal Nutrition. 2013 ; Vol. 23, No. 6. pp. 406-410.
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abstract = "Objective: Albumin and prealbumin are associated with nutritional status and inflammatory status. Each has a residual effect on mortality outcomes when included in regression models that include the other. Prealbumin is increased in the obese mouse model as a consequence of stabilization of prealbumin by retinol binding protein 4 (RBP4) secreted by adipocytes. We carried out this study to establish the contribution of adiposity to prealbumin levels in prevalent patients receiving dialysis and the relationship of prealbumin to RBP4. Design and Methods: We determined whether prealbumin was associated with adiposity in patients receiving hemodialysis (HD), controlling for the effects of inflammation and nutrition. We evaluated body composition in 48 prevalent patients receiving HD by magnetic resonance imaging (MRI), measuring total skeletal muscle mass (SM), visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and serum albumin, prealbumin, RBP4, and interleukin-6 (IL-6) levels. We used normalized protein catabolic rate (nPCR) to report nutrition and separately analyzed the determinants of albumin and then of prealbumin by multiple stepwise regression. Results: Thirty-two patients were women, 16 patients were diabetic, and median age and body mass index were 54.5 and 27.3 kg/m2, respectively. Median total adipose tissue (TAT) was 24.3 kg and VAT was 3.25 kg. Prealbumin was positively associated with VAT, nPCR, and RBP4 and was negatively associated with IL-6; r2 for the model was 0.64. By contrast, albumin was positively associated with nPCR and negatively associated with IL-6 but not with any measure of adiposity (r2 for the model=0.2). Conclusions: Prealbumin, like albumin, is associated with markers of nutrition (nPCR) and inflammation, but unlike albumin, prealbumin levels are positively associated with visceral adiposity.",
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AU - Molfino, Alessio

AU - Heymsfield, Steven B.

AU - Zhu, Fansan

AU - Kotanko, Peter

AU - Levin, Nathan W.

AU - Dwyer, Tjien

AU - Kaysen, George

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