Pre-targeted immunoscintigraphy of murine tumors with indium-111-labeled bifunctional haptens

D. A. Goodwin, C. F. Meares, M. J. McCall, M. McTigue, W. Chaovapong

Research output: Contribution to journalArticle

201 Scopus citations

Abstract

A method of tumor imaging utilizing the nonspecific accumulation of antibody through leaky capillaries is described, in which the antibody and the radiolabel are administered separately. Nonradioactive antibody is given first (pre-targeted), and allowed adequate time to reach maximum tumor concentration. Depending on the antibody, this may take several days. At the time of maximum tumor concentration of nonradioactive antibody, the blood is quickly cleared of excess circulating nonradioactive antibody using a special i.v. 'chase'. The radiolabel then is given and imaging done in 1 to 3 hr. The use of short lived tracers (hours) to image antibodies that localize slowly (days) in-vivo is made possible by this method.

Original languageEnglish (US)
Pages (from-to)226-234
Number of pages9
JournalJournal of Nuclear Medicine
Volume29
Issue number2
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

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    Goodwin, D. A., Meares, C. F., McCall, M. J., McTigue, M., & Chaovapong, W. (1988). Pre-targeted immunoscintigraphy of murine tumors with indium-111-labeled bifunctional haptens. Journal of Nuclear Medicine, 29(2), 226-234.