Pre- and postnatal polychlorinated biphenyl exposure and cognitive and behavioral development at age 45 Months in a cohort of Slovak children

Regina M. Simeone, Penelope P. Howards, Elizabeth Anderson, Todd A. Jusko, Beata Drobná, Anton Kočan, Kamil Čonka, Anna Fabišiková, Ľubica Palkovičová Murínová, Richard L. Canfield, Dean Sonneborn, Soňa Wimmerová, Kelly Thevenet-Morrison, Tomáš Trnovec, Irva Hertz-Picciotto, Eva Šovčíková

Research output: Contribution to journalArticlepeer-review

Abstract

Evidence of associations of pre- and postnatal exposure to polychlorinated biphenyls (PCBs) with cognitive development beyond early childhood is inconsistent. A previous report from this cohort observed adverse associations between early life PCB exposures and infant Bayley scores at age 16 months. The present study examines pre- and postnatal PCB exposures in relation to both behavior and cognitive development at age 45 months. Participants were 472 mother-child pairs residing in an area of eastern Slovakia characterized by environmental contamination with PCBs, which resulted in elevated blood serum concentrations. PCB-153 and PCB-118 concentrations were measured in maternal and in infant 6-, 16-, and 45-month serum samples. At age 45 months, children were administered five subtests of the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-III), and mothers completed the Child Behavior Checklist (CBCL). Negative binomial and multiple linear regressions were used to estimate PCB—CBCL and PCB—WPPSI-III subtest score associations, respectively. Pre- and postnatal levels of PCB-153 and PCB-118 were not associated with cognitive performance on the WPPSI-III in this cohort. There was some suggestion that higher postnatal PCB concentrations were associated with more sleep problems and feelings of depression and anxiousness.

Original languageEnglish (US)
Article number132375
JournalChemosphere
Volume287
DOIs
StatePublished - Jan 2022

Keywords

  • Child behavior checklist
  • Polychlorinated biphenyls
  • Slovakia
  • Wechsler preschool and primary scale of intelligence-III

ASJC Scopus subject areas

  • Environmental Engineering
  • Chemistry(all)
  • Environmental Chemistry
  • Pollution
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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