Practical guidelines on the use of insulin lispro in elderly diabetic patients

Mahmoud M. Benbarka, Pamela T Prescott, Thomas T. Aoki

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Glucose tolerance deteriorates, and the prevalence of diabetes mellitus increases, with advancing age. Most elderly diabetic patients have type 2 (non-insulin-dependent) diabetes mellitus, but the prolonged survival of young people with type 1 (insulin-dependent) diabetes mellitus increases the prevalence of type 1 diabetes among the elderly. Approximately 25 to 29% of patients with type 2 diabetes mellitus are treated with insulin. Conventional therapy with regular and intermediate-acting insulin preparations does not mimic physiological insulin secretion. Subcutaneous administration of insulin lispro, a recently introduced insulin analogue, more closely mimics the time-action curve of endogenous insulin that is produced in response to meals. Its rapid onset and short duration of action allow for adequate control of postprandial glucose levels while reducing the risk of late postprandial hypoglycaemia. Insulin lispro offers improved glycaemic control, convenience and increased flexibility in insulin-treated patients with diabetes.

Original languageEnglish (US)
Pages (from-to)103-113
Number of pages11
JournalDrugs and Aging
Issue number2
StatePublished - 1998

ASJC Scopus subject areas

  • Pharmacology
  • Geriatrics and Gerontology


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