Potentiatied anti-tumor effectiveness of combined therapy with interleukin-12 and mitoxantrone of L1210 leukemia in vivo

Jakub Golab, Radoslaw Zagozdzon, Katarzyna Kozar, Rafal Kaminski, Adam Giermasz, Tomasz Stoklosa, Witold Lasek, Marek Jakóbisiak

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

In previous studies we have shown that combined chemo-immunotherapy of L1210 leukemia with IL-12 and doxorubicin results in striking anti-tumor effects producing 100% of long-term survivors. In this study we investigated the efficacy of a combination of IL-12 and mitoxantrone in murine L1210 leukemia. Mice inoculated with 1×105 leukemia cells were treated with a single dose of mitoxantrone and seven daily doses of IL-12, and were daily observed for survival. Treatment with IL-12 or mitoxantrone given alone produced moderate anti-leukemic effects. However, combination of both drugs resulted in a significant prolongation of mouse survival time. Importantly, there were almost 50% of long-term (>60 days) survivors among the mice treated with both agents. This therapeutic effect was completely abrogated by sub-lethal, whole-body X-irradiation, and significantly reduced after macrophage depletion.

Original languageEnglish (US)
Pages (from-to)177-181
Number of pages5
JournalOncology Reports
Volume7
Issue number1
StatePublished - 2000
Externally publishedYes

Keywords

  • Chemoimmunotherapy
  • Interleukin-12
  • L1210 leukemia
  • Macrophages
  • Mitoxantrone

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Golab, J., Zagozdzon, R., Kozar, K., Kaminski, R., Giermasz, A., Stoklosa, T., Lasek, W., & Jakóbisiak, M. (2000). Potentiatied anti-tumor effectiveness of combined therapy with interleukin-12 and mitoxantrone of L1210 leukemia in vivo. Oncology Reports, 7(1), 177-181.