Potentiated antitumor effects of interleukin 12 and interferon alpha against B16F10 melanoma in mice

A. Dabrowska, Adam Giermasz, J. Golab, M. Jakóbisiak

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Systemic administration of cytokines has not found broad application in cancer immunotherapy due to its toxicity and lack of effectiveness in a broad spectrum of tumors. Among the most promising cytokines used often in pre-clinical and clinical trials are interferon alpha and interleukin 12. We have shown in our study that combining IL-12 with IFN-α in a dose which alone does not show antitumor activity results in potentiated antitumor effects without inducing toxicity.

Original languageEnglish (US)
Pages (from-to)358-361
Number of pages4
JournalNeoplasma
Volume48
Issue number5
StatePublished - 2001
Externally publishedYes

Keywords

  • Interferon alpha
  • Interleukin 12
  • Melanoma
  • Mice

ASJC Scopus subject areas

  • Cancer Research

Fingerprint Dive into the research topics of 'Potentiated antitumor effects of interleukin 12 and interferon alpha against B16F10 melanoma in mice'. Together they form a unique fingerprint.

  • Cite this