Potential use of nucleic acid-based agents in the sensitization of nasopharyngeal carcinoma to radiotherapy

Lu Zhang, Lifang Yang, Jian-Jian Li, Lunquan Sun

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Nasopharyngeal carcinoma (NPC) is a highly metastatic cancer. The 2-year survival rate of patients with stage III or IV disease is only about 50%. Due to its high radiosensitivity, radiotherapy is the standard treatment for early-stage of NPC. However, the radioresistance observed in some patients can cause distant metastases and local recurrence after radiotherapy. Special emphasis has been given to the discovery of effective radiosensitizers. Oncogenic proteins encoded by EBV genomes may serve as part of targeted radiosensitization, such as NF k{cyrillic}B-mediated expression of latent membrane protein-1. We here review the major nucleic acid-based options currently used in cancer therapeutic approaches and the selected candidate genes that can be targeted for NPC radiosensitization.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalCancer Letters
Volume323
Issue number1
DOIs
StatePublished - Oct 1 2012

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Keywords

  • Nasopharyngeal carcinoma
  • Nucleic acid-based agents
  • Radiotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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