Potential role of epigenetic mechanisms in the regulation of drug metabolism and transport

Magnus Ingelman-Sundberg, Xiao Bo Zhong, Oliver Hankinson, Sudheer Beedanagari, Aiming Yu, Lai Peng, Yoichi Osawa

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

This is a report of a symposium on the potential role of epigenetic mechanisms in the control of drug disposition sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the Experimental Biology 2013 meeting in Boston, MA, April 21, 2013. Epigenetics is a rapidly evolving area, and recent studies have revealed that expression of drug-metabolizing enzymes and transporters is regulated by epigenetic factors, including histone modification, DNA methylation, and noncoding RNAs. The symposium speakers provided an overview of genetic and epigenetic mechanisms underlying variable drug metabolism and drug response, as well as the implications for personalized medicine. Considerable insight into the epigenetic mechanisms in differential regulation of the dioxin-inducible drug and carcinogen-metabolizing enzymes CYP1A1 and1B1 was provided. The role of noncoding microRNAs in the control of drug metabolism and disposition through targeting of cytochrome P450 (P450) enzymes and ATP-binding cassette membrane transporters was discussed. In addition, potential effects of xenobiotics on chromatin interactions and epigenomics, as well as the possible role of long noncoding RNAs in regulation of P450s during liver maturation were presented.

Original languageEnglish (US)
Pages (from-to)1725-1731
Number of pages7
JournalDrug Metabolism and Disposition
Volume41
Issue number10
DOIs
StatePublished - Oct 2013

Fingerprint

Drug and Narcotic Control
Epigenomics
Pharmaceutical Preparations
Cytochrome P-450 Enzyme System
Histone Code
Long Noncoding RNA
Untranslated RNA
Precision Medicine
Cytochrome P-450 CYP1A1
Dioxins
ATP-Binding Cassette Transporters
Membrane Transport Proteins
Xenobiotics
DNA Methylation
Enzymes
MicroRNAs
Carcinogens
Chromatin
Liver

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Cite this

Ingelman-Sundberg, M., Zhong, X. B., Hankinson, O., Beedanagari, S., Yu, A., Peng, L., & Osawa, Y. (2013). Potential role of epigenetic mechanisms in the regulation of drug metabolism and transport. Drug Metabolism and Disposition, 41(10), 1725-1731. https://doi.org/10.1124/dmd.113.053157

Potential role of epigenetic mechanisms in the regulation of drug metabolism and transport. / Ingelman-Sundberg, Magnus; Zhong, Xiao Bo; Hankinson, Oliver; Beedanagari, Sudheer; Yu, Aiming; Peng, Lai; Osawa, Yoichi.

In: Drug Metabolism and Disposition, Vol. 41, No. 10, 10.2013, p. 1725-1731.

Research output: Contribution to journalArticle

Ingelman-Sundberg, M, Zhong, XB, Hankinson, O, Beedanagari, S, Yu, A, Peng, L & Osawa, Y 2013, 'Potential role of epigenetic mechanisms in the regulation of drug metabolism and transport', Drug Metabolism and Disposition, vol. 41, no. 10, pp. 1725-1731. https://doi.org/10.1124/dmd.113.053157
Ingelman-Sundberg, Magnus ; Zhong, Xiao Bo ; Hankinson, Oliver ; Beedanagari, Sudheer ; Yu, Aiming ; Peng, Lai ; Osawa, Yoichi. / Potential role of epigenetic mechanisms in the regulation of drug metabolism and transport. In: Drug Metabolism and Disposition. 2013 ; Vol. 41, No. 10. pp. 1725-1731.
@article{86821fcfe8584745b650d1d8e864c138,
title = "Potential role of epigenetic mechanisms in the regulation of drug metabolism and transport",
abstract = "This is a report of a symposium on the potential role of epigenetic mechanisms in the control of drug disposition sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the Experimental Biology 2013 meeting in Boston, MA, April 21, 2013. Epigenetics is a rapidly evolving area, and recent studies have revealed that expression of drug-metabolizing enzymes and transporters is regulated by epigenetic factors, including histone modification, DNA methylation, and noncoding RNAs. The symposium speakers provided an overview of genetic and epigenetic mechanisms underlying variable drug metabolism and drug response, as well as the implications for personalized medicine. Considerable insight into the epigenetic mechanisms in differential regulation of the dioxin-inducible drug and carcinogen-metabolizing enzymes CYP1A1 and1B1 was provided. The role of noncoding microRNAs in the control of drug metabolism and disposition through targeting of cytochrome P450 (P450) enzymes and ATP-binding cassette membrane transporters was discussed. In addition, potential effects of xenobiotics on chromatin interactions and epigenomics, as well as the possible role of long noncoding RNAs in regulation of P450s during liver maturation were presented.",
author = "Magnus Ingelman-Sundberg and Zhong, {Xiao Bo} and Oliver Hankinson and Sudheer Beedanagari and Aiming Yu and Lai Peng and Yoichi Osawa",
year = "2013",
month = "10",
doi = "10.1124/dmd.113.053157",
language = "English (US)",
volume = "41",
pages = "1725--1731",
journal = "Drug Metabolism and Disposition",
issn = "0090-9556",
publisher = "American Society for Pharmacology and Experimental Therapeutics",
number = "10",

}

TY - JOUR

T1 - Potential role of epigenetic mechanisms in the regulation of drug metabolism and transport

AU - Ingelman-Sundberg, Magnus

AU - Zhong, Xiao Bo

AU - Hankinson, Oliver

AU - Beedanagari, Sudheer

AU - Yu, Aiming

AU - Peng, Lai

AU - Osawa, Yoichi

PY - 2013/10

Y1 - 2013/10

N2 - This is a report of a symposium on the potential role of epigenetic mechanisms in the control of drug disposition sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the Experimental Biology 2013 meeting in Boston, MA, April 21, 2013. Epigenetics is a rapidly evolving area, and recent studies have revealed that expression of drug-metabolizing enzymes and transporters is regulated by epigenetic factors, including histone modification, DNA methylation, and noncoding RNAs. The symposium speakers provided an overview of genetic and epigenetic mechanisms underlying variable drug metabolism and drug response, as well as the implications for personalized medicine. Considerable insight into the epigenetic mechanisms in differential regulation of the dioxin-inducible drug and carcinogen-metabolizing enzymes CYP1A1 and1B1 was provided. The role of noncoding microRNAs in the control of drug metabolism and disposition through targeting of cytochrome P450 (P450) enzymes and ATP-binding cassette membrane transporters was discussed. In addition, potential effects of xenobiotics on chromatin interactions and epigenomics, as well as the possible role of long noncoding RNAs in regulation of P450s during liver maturation were presented.

AB - This is a report of a symposium on the potential role of epigenetic mechanisms in the control of drug disposition sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the Experimental Biology 2013 meeting in Boston, MA, April 21, 2013. Epigenetics is a rapidly evolving area, and recent studies have revealed that expression of drug-metabolizing enzymes and transporters is regulated by epigenetic factors, including histone modification, DNA methylation, and noncoding RNAs. The symposium speakers provided an overview of genetic and epigenetic mechanisms underlying variable drug metabolism and drug response, as well as the implications for personalized medicine. Considerable insight into the epigenetic mechanisms in differential regulation of the dioxin-inducible drug and carcinogen-metabolizing enzymes CYP1A1 and1B1 was provided. The role of noncoding microRNAs in the control of drug metabolism and disposition through targeting of cytochrome P450 (P450) enzymes and ATP-binding cassette membrane transporters was discussed. In addition, potential effects of xenobiotics on chromatin interactions and epigenomics, as well as the possible role of long noncoding RNAs in regulation of P450s during liver maturation were presented.

UR - http://www.scopus.com/inward/record.url?scp=84884686896&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84884686896&partnerID=8YFLogxK

U2 - 10.1124/dmd.113.053157

DO - 10.1124/dmd.113.053157

M3 - Article

C2 - 23918665

AN - SCOPUS:84884686896

VL - 41

SP - 1725

EP - 1731

JO - Drug Metabolism and Disposition

JF - Drug Metabolism and Disposition

SN - 0090-9556

IS - 10

ER -