Potential mechanisms in the early mortality of juvenile Chinook salmon exposed concurrently to infectious hematopoietic Necrosis Virus (IHNV) and esfenvalerate

Mark A. Cliford, Lizabeth Bowen, Jeffrey L Stott, Ingeborg Werner, Ronald Hedrick

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Replicate groups of juvenile Chinook salmon (Oncorhynchus tshawytscha) were exposed to infectious hematopoietic necrosis virus (IHNV), sub-lethal levels of esfenvalerate, or to both agents concurrently. A lethal synergistic effect of concurrent exposure to IHNV and esfenvalerate resulted in 24.1% mortality by 68 h post-virus exposure with no mortality observed in any other treatment groups at this time. Analyses of spleen samples from fish sampled at 68 h following exposure to both IHNV and esfenvalerate was suggestive of a disruption of transcription, and demonstrated a significant decrease in the production of two early, non-specific anti-viral genes (Mx-1 and Vig-8). Analyses of blood serum suggested that osmolality was not a contributing factor to the observed early mortality event. Examinations of stained sections of the gill and anterior kidney from fish in all treatment groups at 68 h did not reveal pathologic microscopic changes. This study suggests that the lethal synergistic effect of exposure to IHNV and esfenvalerate to juvenile Chinook salmon may be related to inhibited transcription of early, non-specific, anti-viral cytokines.

Original languageEnglish (US)
Pages (from-to)616-629
Number of pages14
JournalCalifornia Fish and Game
Volume100
Issue number4
StatePublished - Sep 1 2015

Fingerprint

esfenvalerate
Infectious hematopoietic necrosis virus
Oncorhynchus tshawytscha
virus
lethal genes
mortality
transcription (genetics)
osmolality
blood serum
fish
gills
spleen
cytokines
kidneys
serum
viruses
blood
necrosis
exposure
gene

Keywords

  • Chinook salmon
  • Esfenvalerate
  • IHNV
  • Mx-1
  • Pesticides
  • Synergy
  • Vig-8

ASJC Scopus subject areas

  • Aquatic Science
  • Animal Science and Zoology

Cite this

Potential mechanisms in the early mortality of juvenile Chinook salmon exposed concurrently to infectious hematopoietic Necrosis Virus (IHNV) and esfenvalerate. / Cliford, Mark A.; Bowen, Lizabeth; Stott, Jeffrey L; Werner, Ingeborg; Hedrick, Ronald.

In: California Fish and Game, Vol. 100, No. 4, 01.09.2015, p. 616-629.

Research output: Contribution to journalArticle

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