Potential Environmental Factors in Amyotrophic Lateral Sclerosis

Bjorn E Oskarsson, D. Kevin Horton, Hiroshi Mitsumoto

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The causes of amyotrophic lateral sclerosis (ALS) are largely unknown, and may always be multiple, including environmental factors. Monogenetic determinants of ALS are involved in roughly 20% of all cases (including 10% familial cases). Less well understood multigenetic causes may contribute to another 20% to 80%. Environmental factors likely play a role in the development of ALS in susceptible individuals, but proved causation remains elusive. This article discusses the possible factors of male gender (males are selectively exposed to different influences, or genetically predisposed to be susceptible), smoking, military service, exercise, electrical exposure, heavy metals, agricultural chemicals, and geographic clusters.

Original languageEnglish (US)
Pages (from-to)877-888
Number of pages12
JournalNeurologic Clinics
Volume33
Issue number4
DOIs
StatePublished - Nov 1 2015

Fingerprint

Amyotrophic Lateral Sclerosis
Agrochemicals
Heavy Metals
Causality
Smoking

Keywords

  • ALS
  • Environmental risk factors
  • Epidemiology
  • Gender
  • Military service
  • Oxidative stress
  • Smoking

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Potential Environmental Factors in Amyotrophic Lateral Sclerosis. / Oskarsson, Bjorn E; Horton, D. Kevin; Mitsumoto, Hiroshi.

In: Neurologic Clinics, Vol. 33, No. 4, 01.11.2015, p. 877-888.

Research output: Contribution to journalArticle

Oskarsson, BE, Horton, DK & Mitsumoto, H 2015, 'Potential Environmental Factors in Amyotrophic Lateral Sclerosis', Neurologic Clinics, vol. 33, no. 4, pp. 877-888. https://doi.org/10.1016/j.ncl.2015.07.009
Oskarsson, Bjorn E ; Horton, D. Kevin ; Mitsumoto, Hiroshi. / Potential Environmental Factors in Amyotrophic Lateral Sclerosis. In: Neurologic Clinics. 2015 ; Vol. 33, No. 4. pp. 877-888.
@article{6c38b4b4bc714fb686e2f0d4a7b198be,
title = "Potential Environmental Factors in Amyotrophic Lateral Sclerosis",
abstract = "The causes of amyotrophic lateral sclerosis (ALS) are largely unknown, and may always be multiple, including environmental factors. Monogenetic determinants of ALS are involved in roughly 20{\%} of all cases (including 10{\%} familial cases). Less well understood multigenetic causes may contribute to another 20{\%} to 80{\%}. Environmental factors likely play a role in the development of ALS in susceptible individuals, but proved causation remains elusive. This article discusses the possible factors of male gender (males are selectively exposed to different influences, or genetically predisposed to be susceptible), smoking, military service, exercise, electrical exposure, heavy metals, agricultural chemicals, and geographic clusters.",
keywords = "ALS, Environmental risk factors, Epidemiology, Gender, Military service, Oxidative stress, Smoking",
author = "Oskarsson, {Bjorn E} and Horton, {D. Kevin} and Hiroshi Mitsumoto",
year = "2015",
month = "11",
day = "1",
doi = "10.1016/j.ncl.2015.07.009",
language = "English (US)",
volume = "33",
pages = "877--888",
journal = "Neurologic Clinics",
issn = "0733-8619",
publisher = "W.B. Saunders Ltd",
number = "4",

}

TY - JOUR

T1 - Potential Environmental Factors in Amyotrophic Lateral Sclerosis

AU - Oskarsson, Bjorn E

AU - Horton, D. Kevin

AU - Mitsumoto, Hiroshi

PY - 2015/11/1

Y1 - 2015/11/1

N2 - The causes of amyotrophic lateral sclerosis (ALS) are largely unknown, and may always be multiple, including environmental factors. Monogenetic determinants of ALS are involved in roughly 20% of all cases (including 10% familial cases). Less well understood multigenetic causes may contribute to another 20% to 80%. Environmental factors likely play a role in the development of ALS in susceptible individuals, but proved causation remains elusive. This article discusses the possible factors of male gender (males are selectively exposed to different influences, or genetically predisposed to be susceptible), smoking, military service, exercise, electrical exposure, heavy metals, agricultural chemicals, and geographic clusters.

AB - The causes of amyotrophic lateral sclerosis (ALS) are largely unknown, and may always be multiple, including environmental factors. Monogenetic determinants of ALS are involved in roughly 20% of all cases (including 10% familial cases). Less well understood multigenetic causes may contribute to another 20% to 80%. Environmental factors likely play a role in the development of ALS in susceptible individuals, but proved causation remains elusive. This article discusses the possible factors of male gender (males are selectively exposed to different influences, or genetically predisposed to be susceptible), smoking, military service, exercise, electrical exposure, heavy metals, agricultural chemicals, and geographic clusters.

KW - ALS

KW - Environmental risk factors

KW - Epidemiology

KW - Gender

KW - Military service

KW - Oxidative stress

KW - Smoking

UR - http://www.scopus.com/inward/record.url?scp=84945925207&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84945925207&partnerID=8YFLogxK

U2 - 10.1016/j.ncl.2015.07.009

DO - 10.1016/j.ncl.2015.07.009

M3 - Article

C2 - 26515627

AN - SCOPUS:84945925207

VL - 33

SP - 877

EP - 888

JO - Neurologic Clinics

JF - Neurologic Clinics

SN - 0733-8619

IS - 4

ER -