Abstract
Data from animal and epidemiological studies suggest that dietary flavonoids protect against the development of vascular disease. Despite the focus of attention on the ability of flavonoids to act as antioxidants and to alter endothelial cell eicosanoid production, a vast number of other mechanisms exist through which flavonoids could function to inhibit the development of vascular disease in humans. Reviewed here are six other factors that can influence the development of vascular disease in humans and the potential impact of flavonoids on each: adhesion receptor expression, bacterial replication, carbohydrate-induced AGE (advanced glycation end product) formation, estrogenic effects, proteolytic enzymes, and viral replication. Reviewed data suggest that if the total plasma flavonoid load exceeds a few micromoles per liter in vivo, flavonoids will protect humans against vascular damage that results from the aforementioned causes. Copyright (C) 1998 Elsevier Science Inc.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 560-566 |
| Number of pages | 7 |
| Journal | Journal of Nutritional Biochemistry |
| Volume | 9 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1998 |
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Keywords
- AGE
- Atherosclerosis
- Estrogen
- Flavonoids
- Immune system
- Vascular disease
ASJC Scopus subject areas
- Biochemistry
- Endocrinology, Diabetes and Metabolism
Cite this
Potential effects of flavonoids on the etiology of vascular disease. / Schramm, Derek D.; German, J. Bruce.
In: Journal of Nutritional Biochemistry, Vol. 9, No. 10, 10.1998, p. 560-566.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Potential effects of flavonoids on the etiology of vascular disease
AU - Schramm, Derek D.
AU - German, J. Bruce
PY - 1998/10
Y1 - 1998/10
N2 - Data from animal and epidemiological studies suggest that dietary flavonoids protect against the development of vascular disease. Despite the focus of attention on the ability of flavonoids to act as antioxidants and to alter endothelial cell eicosanoid production, a vast number of other mechanisms exist through which flavonoids could function to inhibit the development of vascular disease in humans. Reviewed here are six other factors that can influence the development of vascular disease in humans and the potential impact of flavonoids on each: adhesion receptor expression, bacterial replication, carbohydrate-induced AGE (advanced glycation end product) formation, estrogenic effects, proteolytic enzymes, and viral replication. Reviewed data suggest that if the total plasma flavonoid load exceeds a few micromoles per liter in vivo, flavonoids will protect humans against vascular damage that results from the aforementioned causes. Copyright (C) 1998 Elsevier Science Inc.
AB - Data from animal and epidemiological studies suggest that dietary flavonoids protect against the development of vascular disease. Despite the focus of attention on the ability of flavonoids to act as antioxidants and to alter endothelial cell eicosanoid production, a vast number of other mechanisms exist through which flavonoids could function to inhibit the development of vascular disease in humans. Reviewed here are six other factors that can influence the development of vascular disease in humans and the potential impact of flavonoids on each: adhesion receptor expression, bacterial replication, carbohydrate-induced AGE (advanced glycation end product) formation, estrogenic effects, proteolytic enzymes, and viral replication. Reviewed data suggest that if the total plasma flavonoid load exceeds a few micromoles per liter in vivo, flavonoids will protect humans against vascular damage that results from the aforementioned causes. Copyright (C) 1998 Elsevier Science Inc.
KW - AGE
KW - Atherosclerosis
KW - Estrogen
KW - Flavonoids
KW - Immune system
KW - Vascular disease
UR - http://www.scopus.com/inward/record.url?scp=0032188899&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032188899&partnerID=8YFLogxK
U2 - 10.1016/S0955-2863(98)00051-5
DO - 10.1016/S0955-2863(98)00051-5
M3 - Article
AN - SCOPUS:0032188899
VL - 9
SP - 560
EP - 566
JO - Journal of Nutritional Biochemistry
JF - Journal of Nutritional Biochemistry
SN - 0955-2863
IS - 10
ER -