Potential clinical applications of a new method for quantitation of plasma levels of 5-fluorouracil and 5-fluorodeoxyuridine

R. A. Jones, Alan R Buckpitt, H. H. Londer, C. E. Myers, B. A. Chabner, M. R. Boyd

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A new high-pressure liquid chromatographic method for the clinical assay of 5-fluorouracil and 5-fluorodeoxyuridine has been developed. The sensitivity and specificity of the method equals that of gas chromatography/mass spectrometric methods. The practical value of the method has been demonstrated by its application in several preliminary clinical studies of 5-fluorouracil in which plasma levels of 10-8-10-6M were readily monitored.

Original languageEnglish (US)
Pages (from-to)75-78
Number of pages4
JournalBulletin du Cancer
Volume66
Issue number1
StatePublished - 1979
Externally publishedYes

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Floxuridine
Fluorouracil
Gas Chromatography
Pressure
Sensitivity and Specificity

ASJC Scopus subject areas

  • Oncology

Cite this

Potential clinical applications of a new method for quantitation of plasma levels of 5-fluorouracil and 5-fluorodeoxyuridine. / Jones, R. A.; Buckpitt, Alan R; Londer, H. H.; Myers, C. E.; Chabner, B. A.; Boyd, M. R.

In: Bulletin du Cancer, Vol. 66, No. 1, 1979, p. 75-78.

Research output: Contribution to journalArticle

Jones, R. A. ; Buckpitt, Alan R ; Londer, H. H. ; Myers, C. E. ; Chabner, B. A. ; Boyd, M. R. / Potential clinical applications of a new method for quantitation of plasma levels of 5-fluorouracil and 5-fluorodeoxyuridine. In: Bulletin du Cancer. 1979 ; Vol. 66, No. 1. pp. 75-78.
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