Potential anti-atherosclerotic effects of dipeptidyl peptidase-4 inhibitors in type 2 diabetes mellitus topical collection on macrovascular complications in diabetes

Sandeep Dhindsa, Ishwarlal Jialal

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Cardiovascular disease (CVD) is the leading cause of mortality in patients with diabetes. Pharmacotherapy that can reduce hyperglycemia and also exhibit pleiotropic effects that can result in a reduction in cardiovascular disease will be a major advance. Recently, the dipeptidyl-peptidase-4 inhibitors were introduced as ant-hyperglycemic therapy. Studies from numerous groups have reported effects that could potentially result in a reduction in CVD. Some of the drugs in this class, especially vildagliptin and sitagliptin, have been shown to reduce postprandial hyperlipidemia following a fat load, improve endothelial function as evidenced by increased forearm blood flow, and also display anti-inflammatory effects. Their effects on platelet function, blood pressure, and oxidative stress are very preliminary and need to be confirmed. Finally, they have been shown to reduce subclinical atherosclerosis by reducing carotid intimal-medial thickness. However, the final arbiter with respect to a reduction in CVD will be the ongoing clinical trials.

Original languageEnglish (US)
Article number463
JournalCurrent Diabetes Reports
Volume14
Issue number2
DOIs
StatePublished - Feb 2014

Keywords

  • Antioxidant
  • Atherosclerosis
  • CD26
  • CRP
  • Diabetes
  • Dipeptidyl peptidase 4
  • DPP-4
  • Endothelial function
  • Inflammation
  • Lipids
  • Postprandial hyperlipidemia
  • T2DM

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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