Potassium channels in the heart: Structure, function and regulation

Eleonora Grandi, Michael C. Sanguinetti, Daniel C. Bartos, Donald M Bers, Ye Chen-Izu, Nipavan Chiamvimonvat, Henry M. Colecraft, Brian P. Delisle, Jordi Heijman, Manuel F Navedo, Sergei Noskov, Catherine Proenza, Jamie I. Vandenberg, Vladimir Yarov-Yarovoy

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

This paper is the outcome of the fourth UC Davis Systems Approach to Understanding Cardiac Excitation-Contraction Coupling and Arrhythmias Symposium, a biannual event that aims to bring together leading experts in subfields of cardiovascular biomedicine to focus on topics of importance to the field. The theme of the 2016 symposium was 'K+ Channels and Regulation'. Experts in the field contributed their experimental and mathematical modelling perspectives and discussed emerging questions, controversies and challenges on the topic of cardiac K+ channels. This paper summarizes the topics of formal presentations and informal discussions from the symposium on the structural basis of voltage-gated K+ channel function, as well as the mechanisms involved in regulation of K+ channel gating, expression and membrane localization. Given the critical role for K+ channels in determining the rate of cardiac repolarization, it is hardly surprising that essentially every aspect of K+ channel function is exquisitely regulated in cardiac myocytes. This regulation is complex and highly interrelated to other aspects of myocardial function. K+ channel regulatory mechanisms alter, and are altered by, physiological challenges, pathophysiological conditions, and pharmacological agents. An accompanying paper focuses on the integrative role of K+ channels in cardiac electrophysiology, i.e. how K+ currents shape the cardiac action potential, and how their dysfunction can lead to arrhythmias, and discusses K+ channel-based therapeutics. A fundamental understanding of K+ channel regulatory mechanisms and disease processes is fundamental to reveal new targets for human therapy.

Original languageEnglish (US)
JournalJournal of Physiology
DOIs
StateAccepted/In press - 2016

Keywords

  • Gating
  • Heterogeneity
  • Phosphorylation
  • Trafficking

ASJC Scopus subject areas

  • Physiology

Fingerprint Dive into the research topics of 'Potassium channels in the heart: Structure, function and regulation'. Together they form a unique fingerprint.

  • Cite this

    Grandi, E., Sanguinetti, M. C., Bartos, D. C., Bers, D. M., Chen-Izu, Y., Chiamvimonvat, N., Colecraft, H. M., Delisle, B. P., Heijman, J., Navedo, M. F., Noskov, S., Proenza, C., Vandenberg, J. I., & Yarov-Yarovoy, V. (Accepted/In press). Potassium channels in the heart: Structure, function and regulation. Journal of Physiology. https://doi.org/10.1113/JP272864