Potassium channel phosphorylation in excitable cells

Providing dynamic functional variability to a diverse family of ion channels

Kang Sik Park, Jae Won Yang, Edward Seikel, James Trimmer

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Phosphorylation of potassium channels affects their function and plays a major role in regulating cell physiology. Here, we review previous studies of potassium channel phosphorylation, focusing first on studies employing site-directed mutagenesis of recombinant channels expressed in heterologous cells. We then discuss recent mass spectrometric-based approaches to identify and quantify phosphorylation at specific sites on native and recombinant potassium channels, and newly developed mass spectrometric-based techniques that may prove beneficial to future studies of potassium channel phosphorylation, its regulation, and its mechanism of channel modulation.

Original languageEnglish (US)
Pages (from-to)49-57
Number of pages9
JournalPhysiology
Volume23
Issue number1
DOIs
StatePublished - Feb 2008

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Potassium Channels
Ion Channels
Phosphorylation
Cell Physiological Phenomena
Site-Directed Mutagenesis

ASJC Scopus subject areas

  • Physiology

Cite this

Potassium channel phosphorylation in excitable cells : Providing dynamic functional variability to a diverse family of ion channels. / Park, Kang Sik; Yang, Jae Won; Seikel, Edward; Trimmer, James.

In: Physiology, Vol. 23, No. 1, 02.2008, p. 49-57.

Research output: Contribution to journalArticle

Park, Kang Sik ; Yang, Jae Won ; Seikel, Edward ; Trimmer, James. / Potassium channel phosphorylation in excitable cells : Providing dynamic functional variability to a diverse family of ion channels. In: Physiology. 2008 ; Vol. 23, No. 1. pp. 49-57.
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