Potassium channel phosphorylation in excitable cells: Providing dynamic functional variability to a diverse family of ion channels

Kang Sik Park, Jae Won Yang, Edward Seikel, James Trimmer

Research output: Contribution to journalArticle

40 Scopus citations


Phosphorylation of potassium channels affects their function and plays a major role in regulating cell physiology. Here, we review previous studies of potassium channel phosphorylation, focusing first on studies employing site-directed mutagenesis of recombinant channels expressed in heterologous cells. We then discuss recent mass spectrometric-based approaches to identify and quantify phosphorylation at specific sites on native and recombinant potassium channels, and newly developed mass spectrometric-based techniques that may prove beneficial to future studies of potassium channel phosphorylation, its regulation, and its mechanism of channel modulation.

Original languageEnglish (US)
Pages (from-to)49-57
Number of pages9
Issue number1
StatePublished - Feb 2008


ASJC Scopus subject areas

  • Physiology

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