Abstract
It is not conclusively known whether the amplitude of medium latency postural reflexes is controlled by dopamine. To further assess the influence of supraspinal dopaminergic pathways on postural reflexes, we studied short (SL), medium (ML) and long latency (LL) reflexes in the lower extremity of 10 patients on long term (>6 months) neuroleptic medication, 5 with and 5 without mild drug induced parkinsonism. A control group consisted of 10 age and sex matched healthy volunteers. In both patient groups, latencies and amplitudes of all 3 responses were identical to normal controls. These findings suggest that a moderate postsynaptic inhibition of central dopaminergic pathways is insufficient to cause enhanced amplitudes of ML responses.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 119-122 |
| Number of pages | 4 |
| Journal | Clinical Neurology and Neurosurgery |
| Volume | 93 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1991 |
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Keywords
- drug induced parkinsonism
- EMG
- long loop
- medium latency reflexes
- neuroleptics
ASJC Scopus subject areas
- Clinical Neurology
- Surgery
- Neurology
Cite this
Postural reflexes in patients on long-term neuroleptic medication. / Beckley, Dennis J.; Bloem, Bastiaan R.; Singh, Jaswinder; Remler, Michael P.; Wolfe, Nancy S.; A.C. Roos, Raymund.
In: Clinical Neurology and Neurosurgery, Vol. 93, No. 2, 1991, p. 119-122.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Postural reflexes in patients on long-term neuroleptic medication
AU - Beckley, Dennis J.
AU - Bloem, Bastiaan R.
AU - Singh, Jaswinder
AU - Remler, Michael P.
AU - Wolfe, Nancy S.
AU - A.C. Roos, Raymund
PY - 1991
Y1 - 1991
N2 - It is not conclusively known whether the amplitude of medium latency postural reflexes is controlled by dopamine. To further assess the influence of supraspinal dopaminergic pathways on postural reflexes, we studied short (SL), medium (ML) and long latency (LL) reflexes in the lower extremity of 10 patients on long term (>6 months) neuroleptic medication, 5 with and 5 without mild drug induced parkinsonism. A control group consisted of 10 age and sex matched healthy volunteers. In both patient groups, latencies and amplitudes of all 3 responses were identical to normal controls. These findings suggest that a moderate postsynaptic inhibition of central dopaminergic pathways is insufficient to cause enhanced amplitudes of ML responses.
AB - It is not conclusively known whether the amplitude of medium latency postural reflexes is controlled by dopamine. To further assess the influence of supraspinal dopaminergic pathways on postural reflexes, we studied short (SL), medium (ML) and long latency (LL) reflexes in the lower extremity of 10 patients on long term (>6 months) neuroleptic medication, 5 with and 5 without mild drug induced parkinsonism. A control group consisted of 10 age and sex matched healthy volunteers. In both patient groups, latencies and amplitudes of all 3 responses were identical to normal controls. These findings suggest that a moderate postsynaptic inhibition of central dopaminergic pathways is insufficient to cause enhanced amplitudes of ML responses.
KW - drug induced parkinsonism
KW - EMG
KW - long loop
KW - medium latency reflexes
KW - neuroleptics
UR - http://www.scopus.com/inward/record.url?scp=0025923364&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025923364&partnerID=8YFLogxK
U2 - 10.1016/0303-8467(91)90051-P
DO - 10.1016/0303-8467(91)90051-P
M3 - Article
C2 - 1678998
AN - SCOPUS:0025923364
VL - 93
SP - 119
EP - 122
JO - Clinical Neurology and Neurosurgery
JF - Clinical Neurology and Neurosurgery
SN - 0303-8467
IS - 2
ER -