Postural reflexes in patients on long-term neuroleptic medication

Dennis J. Beckley, Bastiaan R. Bloem, Jaswinder Singh, Michael P. Remler, Nancy S. Wolfe, Raymund A.C. Roos

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

It is not conclusively known whether the amplitude of medium latency postural reflexes is controlled by dopamine. To further assess the influence of supraspinal dopaminergic pathways on postural reflexes, we studied short (SL), medium (ML) and long latency (LL) reflexes in the lower extremity of 10 patients on long term (>6 months) neuroleptic medication, 5 with and 5 without mild drug induced parkinsonism. A control group consisted of 10 age and sex matched healthy volunteers. In both patient groups, latencies and amplitudes of all 3 responses were identical to normal controls. These findings suggest that a moderate postsynaptic inhibition of central dopaminergic pathways is insufficient to cause enhanced amplitudes of ML responses.

Original languageEnglish (US)
Pages (from-to)119-122
Number of pages4
JournalClinical Neurology and Neurosurgery
Volume93
Issue number2
DOIs
StatePublished - 1991

Fingerprint

Antipsychotic Agents
Reflex
Parkinsonian Disorders
Lower Extremity
Dopamine
Healthy Volunteers
Control Groups
Pharmaceutical Preparations
Inhibition (Psychology)

Keywords

  • drug induced parkinsonism
  • EMG
  • long loop
  • medium latency reflexes
  • neuroleptics

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery
  • Neurology

Cite this

Beckley, D. J., Bloem, B. R., Singh, J., Remler, M. P., Wolfe, N. S., & A.C. Roos, R. (1991). Postural reflexes in patients on long-term neuroleptic medication. Clinical Neurology and Neurosurgery, 93(2), 119-122. https://doi.org/10.1016/0303-8467(91)90051-P

Postural reflexes in patients on long-term neuroleptic medication. / Beckley, Dennis J.; Bloem, Bastiaan R.; Singh, Jaswinder; Remler, Michael P.; Wolfe, Nancy S.; A.C. Roos, Raymund.

In: Clinical Neurology and Neurosurgery, Vol. 93, No. 2, 1991, p. 119-122.

Research output: Contribution to journalArticle

Beckley, DJ, Bloem, BR, Singh, J, Remler, MP, Wolfe, NS & A.C. Roos, R 1991, 'Postural reflexes in patients on long-term neuroleptic medication', Clinical Neurology and Neurosurgery, vol. 93, no. 2, pp. 119-122. https://doi.org/10.1016/0303-8467(91)90051-P
Beckley, Dennis J. ; Bloem, Bastiaan R. ; Singh, Jaswinder ; Remler, Michael P. ; Wolfe, Nancy S. ; A.C. Roos, Raymund. / Postural reflexes in patients on long-term neuroleptic medication. In: Clinical Neurology and Neurosurgery. 1991 ; Vol. 93, No. 2. pp. 119-122.
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