Posttreatment human papillomavirus testing for recurrent cervical intraepithelial neoplasia: a systematic review

Benjamin K S Chan, Joy Melnikow, Christina A. Slee, Rose Arellanes, George F. Sawaya

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Objective: We conducted a systematic review to evaluate the characteristics of human papillomavirus testing, particularly Hybrid Capture 2, in follow-up evaluations after treatment for cervical intraepithelial neoplasia for the detection of residual or recurrent cervical intraepithelial neoplasia grade ≥ 2. Study Design: Medline was searched for relevant studies that were published between 1992 and September 2007. Of the 1107 citations that were identified, 20 articles met the inclusion criteria. Results: Studies that used polymerase chain reaction testing were too heterogeneous to combine. We identified 5 studies that performed both Hybrid Capture 2 and colposcopy. Pooled sensitivity for Hybrid Capture 2 was 90.7% (95% CI, 75.4-96.9%), and pooled specificity was 74.6% (95% CI, 60.4-85.0%). Pooled sensitivity for cervical cytologic testing was 76.6% (95% CI, 62.0-86.8%), and pooled specificity was 89.7% (95% CI, 22.7-99.6%). Conclusion: Hybrid Capture 2 testing can identify approximately 91% of women with residual or recurrent cervical intraepithelial neoplasia grade ≥ 2; however, approximately 30% of women would undergo colposcopy in follow-up evaluation.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume200
Issue number4
DOIs
StatePublished - Apr 2009

Keywords

  • cervical intraepithelial neoplasia
  • colposcopy
  • Hybrid Capture 2
  • metaanalysis
  • papillomavirus

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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