Posttranscriptional signal integration of engineered riboswitches yields band-pass output

Norihito Muranaka, Yohei Yokobayashi

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Figure Presented Light in the middle: A simple band-pass circuit has been designed using only posttranscriptional components in Escherichia coli (see figure). Two engineered riboswitches were used as the chemical sensor and to implement lowpass/high-pass functions. The two signals were integrated by protein complementation using split CFP fragments to achieve a band-pass response.

Original languageEnglish (US)
Pages (from-to)4653-4655
Number of pages3
JournalAngewandte Chemie - International Edition
Volume49
Issue number27
DOIs
StatePublished - Jun 21 2010

Keywords

  • Band-pass circuits
  • Genetic engineering
  • Protein complementation
  • Riboswitches
  • RNA

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

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