Posttranscriptional regulation of p53 and its targets by RNA-binding proteins

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


p53 tumor suppressor plays a pivotal role in maintaining genomic integrity and preventing cancer development. The importance of p53 in tumor suppression is illustrated by the observation that about 50% human tumor cells have a dysfunctional p53 pathway. Although it has been well accepted that the activity of p53 is mainly controlled through post-translational modifications, recent studies have revealed that posttranscriptional regulations of p53 by various RNA-binding proteins also play a crucial role in modulating p53 activity and its downstream targets.

Original languageEnglish (US)
Pages (from-to)845-849
Number of pages5
JournalCurrent Molecular Medicine
Issue number8
StatePublished - 2008


  • MRNA decay
  • P53
  • Posttranscriptional regulation
  • RNA-binding proteins
  • Translational regulation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Molecular Medicine


Dive into the research topics of 'Posttranscriptional regulation of p53 and its targets by RNA-binding proteins'. Together they form a unique fingerprint.

Cite this