Posttranscriptional regulation of p53 and its targets by RNA-binding proteins

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

p53 tumor suppressor plays a pivotal role in maintaining genomic integrity and preventing cancer development. The importance of p53 in tumor suppression is illustrated by the observation that about 50% human tumor cells have a dysfunctional p53 pathway. Although it has been well accepted that the activity of p53 is mainly controlled through post-translational modifications, recent studies have revealed that posttranscriptional regulations of p53 by various RNA-binding proteins also play a crucial role in modulating p53 activity and its downstream targets.

Original languageEnglish (US)
Pages (from-to)845-849
Number of pages5
JournalCurrent Molecular Medicine
Volume8
Issue number8
DOIs
StatePublished - 2008

Fingerprint

RNA-Binding Proteins
Tumors
Neoplasms
Post Translational Protein Processing
Cells

Keywords

  • MRNA decay
  • P53
  • Posttranscriptional regulation
  • RNA-binding proteins
  • Translational regulation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Molecular Medicine

Cite this

Posttranscriptional regulation of p53 and its targets by RNA-binding proteins. / Zhang, Jin; Chen, Xinbin.

In: Current Molecular Medicine, Vol. 8, No. 8, 2008, p. 845-849.

Research output: Contribution to journalArticle

@article{9229527d14a745dc8fbc6162b967c59c,
title = "Posttranscriptional regulation of p53 and its targets by RNA-binding proteins",
abstract = "p53 tumor suppressor plays a pivotal role in maintaining genomic integrity and preventing cancer development. The importance of p53 in tumor suppression is illustrated by the observation that about 50{\%} human tumor cells have a dysfunctional p53 pathway. Although it has been well accepted that the activity of p53 is mainly controlled through post-translational modifications, recent studies have revealed that posttranscriptional regulations of p53 by various RNA-binding proteins also play a crucial role in modulating p53 activity and its downstream targets.",
keywords = "MRNA decay, P53, Posttranscriptional regulation, RNA-binding proteins, Translational regulation",
author = "Jin Zhang and Xinbin Chen",
year = "2008",
doi = "10.2174/156652408786733748",
language = "English (US)",
volume = "8",
pages = "845--849",
journal = "Current Molecular Medicine",
issn = "1566-5240",
publisher = "Bentham Science Publishers B.V.",
number = "8",

}

TY - JOUR

T1 - Posttranscriptional regulation of p53 and its targets by RNA-binding proteins

AU - Zhang, Jin

AU - Chen, Xinbin

PY - 2008

Y1 - 2008

N2 - p53 tumor suppressor plays a pivotal role in maintaining genomic integrity and preventing cancer development. The importance of p53 in tumor suppression is illustrated by the observation that about 50% human tumor cells have a dysfunctional p53 pathway. Although it has been well accepted that the activity of p53 is mainly controlled through post-translational modifications, recent studies have revealed that posttranscriptional regulations of p53 by various RNA-binding proteins also play a crucial role in modulating p53 activity and its downstream targets.

AB - p53 tumor suppressor plays a pivotal role in maintaining genomic integrity and preventing cancer development. The importance of p53 in tumor suppression is illustrated by the observation that about 50% human tumor cells have a dysfunctional p53 pathway. Although it has been well accepted that the activity of p53 is mainly controlled through post-translational modifications, recent studies have revealed that posttranscriptional regulations of p53 by various RNA-binding proteins also play a crucial role in modulating p53 activity and its downstream targets.

KW - MRNA decay

KW - P53

KW - Posttranscriptional regulation

KW - RNA-binding proteins

KW - Translational regulation

UR - http://www.scopus.com/inward/record.url?scp=59249094289&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=59249094289&partnerID=8YFLogxK

U2 - 10.2174/156652408786733748

DO - 10.2174/156652408786733748

M3 - Article

C2 - 19075680

AN - SCOPUS:59249094289

VL - 8

SP - 845

EP - 849

JO - Current Molecular Medicine

JF - Current Molecular Medicine

SN - 1566-5240

IS - 8

ER -