Posttranscriptional regulation of p53 and its targets by RNA-binding proteins

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

p53 tumor suppressor plays a pivotal role in maintaining genomic integrity and preventing cancer development. The importance of p53 in tumor suppression is illustrated by the observation that about 50% human tumor cells have a dysfunctional p53 pathway. Although it has been well accepted that the activity of p53 is mainly controlled through post-translational modifications, recent studies have revealed that posttranscriptional regulations of p53 by various RNA-binding proteins also play a crucial role in modulating p53 activity and its downstream targets.

Original languageEnglish (US)
Pages (from-to)845-849
Number of pages5
JournalCurrent Molecular Medicine
Volume8
Issue number8
DOIs
StatePublished - 2008

Keywords

  • MRNA decay
  • P53
  • Posttranscriptional regulation
  • RNA-binding proteins
  • Translational regulation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Molecular Medicine

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