Postprandial changes in the content and composition of nonprotein nitrogen in human milk

S. M. Donovan, R. R. Ereman, K. G. Dewey, B. Lonnerdal

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The effect of a meal on human milk (HM) total nitrogen (TN) and nonprotein nitrogen (NPN) content and composition was examined. Two studies were performed in which milk and blood samples were collected 2-3 h after subjects consumed either a test breakfast or lunch. To monitor the rate of transfer of plasma urea into milk, two women were given [15N]2-urea with the meal. Milk TN concentrations were not significantly different from premeal values. However, concentrations of milk NPN, urea nitrogen, and alanine were increased by ≥ 20% over premeal values. [15N]2-Urea appeared in plasma and milk within 15 min and reached maximum enrichments of 10% and 5.5% in plasma and milk, respectively. Several HM NPN components increase in concentration postprandially; however, these concentrations were not always correlated with changes in plasma concentrations, suggesting that milk NPN may also reflect metabolic activities within the mammary gland.

Original languageEnglish (US)
Pages (from-to)1017-1023
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume54
Issue number6
StatePublished - 1991

Fingerprint

nonprotein nitrogen
Human Milk
breast milk
Milk
Nitrogen
milk
Urea
meals (menu)
Meals
urea
Ureaplasma
Lunch
lunch
Breakfast
breakfast
nitrogen
Human Mammary Glands
urea nitrogen
mammary glands
Alanine

Keywords

  • Free amino acids
  • Human milk
  • Nonprotein nitrogen
  • Postprandial
  • Urea

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Donovan, S. M., Ereman, R. R., Dewey, K. G., & Lonnerdal, B. (1991). Postprandial changes in the content and composition of nonprotein nitrogen in human milk. American Journal of Clinical Nutrition, 54(6), 1017-1023.

Postprandial changes in the content and composition of nonprotein nitrogen in human milk. / Donovan, S. M.; Ereman, R. R.; Dewey, K. G.; Lonnerdal, B.

In: American Journal of Clinical Nutrition, Vol. 54, No. 6, 1991, p. 1017-1023.

Research output: Contribution to journalArticle

Donovan, SM, Ereman, RR, Dewey, KG & Lonnerdal, B 1991, 'Postprandial changes in the content and composition of nonprotein nitrogen in human milk', American Journal of Clinical Nutrition, vol. 54, no. 6, pp. 1017-1023.
Donovan, S. M. ; Ereman, R. R. ; Dewey, K. G. ; Lonnerdal, B. / Postprandial changes in the content and composition of nonprotein nitrogen in human milk. In: American Journal of Clinical Nutrition. 1991 ; Vol. 54, No. 6. pp. 1017-1023.
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