Postpartum depression in women with the FMR1 premutation

Roberta W. Obadia, Ana-Maria Iosif, Andreea L. Seritan

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Psychiatric disorders in women with the FMR1 premutation are common and include attention deficit hyperactivity disorder, anxiety, depression, and eating disorders. This pilot study explored the risk factors for postpartum depression (PPD) in women with the premutation. Methods: We conducted a chart review of 50 women premutation carriers with major depressive disorder who had children. Of these, 7 women had a history of major depressive episodes in the postpartum period. The PPD and non-PPD groups were characterized descriptively based on women's age at the time of the psychiatric evaluation, race, ethnicity, education level, IQ, CGG repeat size, comorbid psychiatric conditions, parity, and number of children with fragile X syndrome (FXS). Exact logistic regression was used to analyze the relationship between the number of children with FXS and the risk of PPD. Results: The PPD and non-PPD groups were similar on all variables examined, with the exception of the number of affected children. Each of the 7 women with PPD had at least one child with FXS, whereas a third of the women without PPD had no affected children. For each additional affected child, the risk of PPD increased by 158% (exact odds ratio 2.58, 95% CI 0.99-7.59). Further studies are needed to replicate these findings and to better characterize PPD in female premutation carriers.

Original languageEnglish (US)
Pages (from-to)72-77
Number of pages6
JournalCurrent Psychiatry Reviews
Volume9
Issue number1
DOIs
StatePublished - 2013

Fingerprint

Postpartum Depression
Fragile X Syndrome
Psychiatry
Depression
Major Depressive Disorder
Attention Deficit Disorder with Hyperactivity
Parity
Anxiety Disorders
Postpartum Period
Logistic Models
Odds Ratio
Education

Keywords

  • Female carriers
  • FMR1 premutation
  • Fragile X syndrome (FXS)
  • Major depressive disorder
  • Postpartum depression

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Postpartum depression in women with the FMR1 premutation. / Obadia, Roberta W.; Iosif, Ana-Maria; Seritan, Andreea L.

In: Current Psychiatry Reviews, Vol. 9, No. 1, 2013, p. 72-77.

Research output: Contribution to journalArticle

Obadia, Roberta W. ; Iosif, Ana-Maria ; Seritan, Andreea L. / Postpartum depression in women with the FMR1 premutation. In: Current Psychiatry Reviews. 2013 ; Vol. 9, No. 1. pp. 72-77.
@article{b790e45cc9664b919b9f3861f1814ba7,
title = "Postpartum depression in women with the FMR1 premutation",
abstract = "Background: Psychiatric disorders in women with the FMR1 premutation are common and include attention deficit hyperactivity disorder, anxiety, depression, and eating disorders. This pilot study explored the risk factors for postpartum depression (PPD) in women with the premutation. Methods: We conducted a chart review of 50 women premutation carriers with major depressive disorder who had children. Of these, 7 women had a history of major depressive episodes in the postpartum period. The PPD and non-PPD groups were characterized descriptively based on women's age at the time of the psychiatric evaluation, race, ethnicity, education level, IQ, CGG repeat size, comorbid psychiatric conditions, parity, and number of children with fragile X syndrome (FXS). Exact logistic regression was used to analyze the relationship between the number of children with FXS and the risk of PPD. Results: The PPD and non-PPD groups were similar on all variables examined, with the exception of the number of affected children. Each of the 7 women with PPD had at least one child with FXS, whereas a third of the women without PPD had no affected children. For each additional affected child, the risk of PPD increased by 158{\%} (exact odds ratio 2.58, 95{\%} CI 0.99-7.59). Further studies are needed to replicate these findings and to better characterize PPD in female premutation carriers.",
keywords = "Female carriers, FMR1 premutation, Fragile X syndrome (FXS), Major depressive disorder, Postpartum depression",
author = "Obadia, {Roberta W.} and Ana-Maria Iosif and Seritan, {Andreea L.}",
year = "2013",
doi = "10.2174/157340013805289680",
language = "English (US)",
volume = "9",
pages = "72--77",
journal = "Current Psychiatry Reviews",
issn = "1573-4005",
publisher = "Bentham Science Publishers B.V.",
number = "1",

}

TY - JOUR

T1 - Postpartum depression in women with the FMR1 premutation

AU - Obadia, Roberta W.

AU - Iosif, Ana-Maria

AU - Seritan, Andreea L.

PY - 2013

Y1 - 2013

N2 - Background: Psychiatric disorders in women with the FMR1 premutation are common and include attention deficit hyperactivity disorder, anxiety, depression, and eating disorders. This pilot study explored the risk factors for postpartum depression (PPD) in women with the premutation. Methods: We conducted a chart review of 50 women premutation carriers with major depressive disorder who had children. Of these, 7 women had a history of major depressive episodes in the postpartum period. The PPD and non-PPD groups were characterized descriptively based on women's age at the time of the psychiatric evaluation, race, ethnicity, education level, IQ, CGG repeat size, comorbid psychiatric conditions, parity, and number of children with fragile X syndrome (FXS). Exact logistic regression was used to analyze the relationship between the number of children with FXS and the risk of PPD. Results: The PPD and non-PPD groups were similar on all variables examined, with the exception of the number of affected children. Each of the 7 women with PPD had at least one child with FXS, whereas a third of the women without PPD had no affected children. For each additional affected child, the risk of PPD increased by 158% (exact odds ratio 2.58, 95% CI 0.99-7.59). Further studies are needed to replicate these findings and to better characterize PPD in female premutation carriers.

AB - Background: Psychiatric disorders in women with the FMR1 premutation are common and include attention deficit hyperactivity disorder, anxiety, depression, and eating disorders. This pilot study explored the risk factors for postpartum depression (PPD) in women with the premutation. Methods: We conducted a chart review of 50 women premutation carriers with major depressive disorder who had children. Of these, 7 women had a history of major depressive episodes in the postpartum period. The PPD and non-PPD groups were characterized descriptively based on women's age at the time of the psychiatric evaluation, race, ethnicity, education level, IQ, CGG repeat size, comorbid psychiatric conditions, parity, and number of children with fragile X syndrome (FXS). Exact logistic regression was used to analyze the relationship between the number of children with FXS and the risk of PPD. Results: The PPD and non-PPD groups were similar on all variables examined, with the exception of the number of affected children. Each of the 7 women with PPD had at least one child with FXS, whereas a third of the women without PPD had no affected children. For each additional affected child, the risk of PPD increased by 158% (exact odds ratio 2.58, 95% CI 0.99-7.59). Further studies are needed to replicate these findings and to better characterize PPD in female premutation carriers.

KW - Female carriers

KW - FMR1 premutation

KW - Fragile X syndrome (FXS)

KW - Major depressive disorder

KW - Postpartum depression

UR - http://www.scopus.com/inward/record.url?scp=84875312725&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875312725&partnerID=8YFLogxK

U2 - 10.2174/157340013805289680

DO - 10.2174/157340013805289680

M3 - Article

VL - 9

SP - 72

EP - 77

JO - Current Psychiatry Reviews

JF - Current Psychiatry Reviews

SN - 1573-4005

IS - 1

ER -