Postoperative Complications in the Ahmed Baerveldt Comparison Study during Five Years of Follow-up

Ahmed Baerveldt Comparison Study Group

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Abstract

Purpose To compare the late complications in the Ahmed Baerveldt Comparison Study during 5 years of follow-up. Design Multicenter, prospective randomized clinical trial. Methods setting: Sixteen international clinical centers. study population: Two hundred seventy-six subjects aged 18-85 years with previous intraocular surgery or refractory glaucoma with intraocular pressure of >18 mm Hg. interventions: Ahmed Glaucoma Valve FP7 or Baerveldt Glaucoma Implant BG 101-350. main outcome measures: Late postoperative complications (beyond 3 months), reoperations for complications, and decreased vision from complications. Results Late complications developed in 56 subjects (46.8 ± 4.8 5-year cumulative % ± SE) in the Ahmed Glaucoma Valve group and 67 (56.3 ± 4.7 5-year cumulative % ± SE) in the Baerveldt Glaucoma Implant group (P =.082). The cumulative rates of serious complications were 15.9% and 24.7% in the Ahmed Glaucoma Valve and Baerveldt Glaucoma Implant groups, respectively (P =.034), although this was largely driven by subjects who had tube occlusions in the 2 groups (0.8% in the Ahmed Glaucoma Valve group and 5.7% in the Baerveldt Glaucoma Implant group, P =.037). Both groups had a relatively high incidence of persistent diplopia (12%) and corneal edema (20%), although half of the corneal edema cases were likely due to pre-existing causes other than the aqueous shunt. The incidence of tube erosion was 1% and 3% in the Ahmed Glaucoma Valve and Baerveldt Glaucoma Implant groups, respectively (P =.04). Conclusions Long-term rates of vision-threatening complications and complications resulting in reoperation were higher in the Baerveldt Glaucoma Implant than in the Ahmed Glaucoma Valve group over 5 years of follow-up.

Original languageEnglish (US)
Pages (from-to)75-82e3
JournalAmerican Journal of Ophthalmology
Volume163
DOIs
StatePublished - Mar 1 2016

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Glaucoma
Glaucoma Drainage Implants
Corneal Edema
Reoperation
Diplopia
Incidence
Intraocular Pressure
Randomized Controlled Trials
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Ophthalmology

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Postoperative Complications in the Ahmed Baerveldt Comparison Study during Five Years of Follow-up. / Ahmed Baerveldt Comparison Study Group.

In: American Journal of Ophthalmology, Vol. 163, 01.03.2016, p. 75-82e3.

Research output: Contribution to journalArticle

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title = "Postoperative Complications in the Ahmed Baerveldt Comparison Study during Five Years of Follow-up",
abstract = "Purpose To compare the late complications in the Ahmed Baerveldt Comparison Study during 5 years of follow-up. Design Multicenter, prospective randomized clinical trial. Methods setting: Sixteen international clinical centers. study population: Two hundred seventy-six subjects aged 18-85 years with previous intraocular surgery or refractory glaucoma with intraocular pressure of >18 mm Hg. interventions: Ahmed Glaucoma Valve FP7 or Baerveldt Glaucoma Implant BG 101-350. main outcome measures: Late postoperative complications (beyond 3 months), reoperations for complications, and decreased vision from complications. Results Late complications developed in 56 subjects (46.8 ± 4.8 5-year cumulative {\%} ± SE) in the Ahmed Glaucoma Valve group and 67 (56.3 ± 4.7 5-year cumulative {\%} ± SE) in the Baerveldt Glaucoma Implant group (P =.082). The cumulative rates of serious complications were 15.9{\%} and 24.7{\%} in the Ahmed Glaucoma Valve and Baerveldt Glaucoma Implant groups, respectively (P =.034), although this was largely driven by subjects who had tube occlusions in the 2 groups (0.8{\%} in the Ahmed Glaucoma Valve group and 5.7{\%} in the Baerveldt Glaucoma Implant group, P =.037). Both groups had a relatively high incidence of persistent diplopia (12{\%}) and corneal edema (20{\%}), although half of the corneal edema cases were likely due to pre-existing causes other than the aqueous shunt. The incidence of tube erosion was 1{\%} and 3{\%} in the Ahmed Glaucoma Valve and Baerveldt Glaucoma Implant groups, respectively (P =.04). Conclusions Long-term rates of vision-threatening complications and complications resulting in reoperation were higher in the Baerveldt Glaucoma Implant than in the Ahmed Glaucoma Valve group over 5 years of follow-up.",
author = "{Ahmed Baerveldt Comparison Study Group} and Budenz, {Donald L.} and Feuer, {William J.} and Keith Barton and Joyce Schiffman and Costa, {Vital P.} and Godfrey, {David G.} and Buys, {Yvonne M.} and Gedde, {Steven J.} and {El Sayyad}, Fouad and Leon Herndon and Ronald Fellman and James Robinson and David Dueker and Patrick Riedel and Thomas Samuelson and Renata Puertas and Paul Chew and Cecilia Aquino and Solish, {Alfred M.} and Graham Trope and Brandt, {James D} and Lim, {Michele C} and Simon Law and Steve Sarkisian and Vikas Chopra and Brian Francis and Mario Meallet and Rohit Varma and Peter Netland and Sarwat Salim and Robert Feldman and Nicholas Bell and Philip Chen and Dale Heuer and Kuldev Singh and Martha Wright and Schiffman, {Joyce C.} and Wei Shi and Luz Ajuria and Yolanda Silva",
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T1 - Postoperative Complications in the Ahmed Baerveldt Comparison Study during Five Years of Follow-up

AU - Ahmed Baerveldt Comparison Study Group

AU - Budenz, Donald L.

AU - Feuer, William J.

AU - Barton, Keith

AU - Schiffman, Joyce

AU - Costa, Vital P.

AU - Godfrey, David G.

AU - Buys, Yvonne M.

AU - Gedde, Steven J.

AU - El Sayyad, Fouad

AU - Herndon, Leon

AU - Fellman, Ronald

AU - Robinson, James

AU - Dueker, David

AU - Riedel, Patrick

AU - Samuelson, Thomas

AU - Puertas, Renata

AU - Chew, Paul

AU - Aquino, Cecilia

AU - Solish, Alfred M.

AU - Trope, Graham

AU - Brandt, James D

AU - Lim, Michele C

AU - Law, Simon

AU - Sarkisian, Steve

AU - Chopra, Vikas

AU - Francis, Brian

AU - Meallet, Mario

AU - Varma, Rohit

AU - Netland, Peter

AU - Salim, Sarwat

AU - Feldman, Robert

AU - Bell, Nicholas

AU - Chen, Philip

AU - Heuer, Dale

AU - Singh, Kuldev

AU - Wright, Martha

AU - Schiffman, Joyce C.

AU - Shi, Wei

AU - Ajuria, Luz

AU - Silva, Yolanda

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Purpose To compare the late complications in the Ahmed Baerveldt Comparison Study during 5 years of follow-up. Design Multicenter, prospective randomized clinical trial. Methods setting: Sixteen international clinical centers. study population: Two hundred seventy-six subjects aged 18-85 years with previous intraocular surgery or refractory glaucoma with intraocular pressure of >18 mm Hg. interventions: Ahmed Glaucoma Valve FP7 or Baerveldt Glaucoma Implant BG 101-350. main outcome measures: Late postoperative complications (beyond 3 months), reoperations for complications, and decreased vision from complications. Results Late complications developed in 56 subjects (46.8 ± 4.8 5-year cumulative % ± SE) in the Ahmed Glaucoma Valve group and 67 (56.3 ± 4.7 5-year cumulative % ± SE) in the Baerveldt Glaucoma Implant group (P =.082). The cumulative rates of serious complications were 15.9% and 24.7% in the Ahmed Glaucoma Valve and Baerveldt Glaucoma Implant groups, respectively (P =.034), although this was largely driven by subjects who had tube occlusions in the 2 groups (0.8% in the Ahmed Glaucoma Valve group and 5.7% in the Baerveldt Glaucoma Implant group, P =.037). Both groups had a relatively high incidence of persistent diplopia (12%) and corneal edema (20%), although half of the corneal edema cases were likely due to pre-existing causes other than the aqueous shunt. The incidence of tube erosion was 1% and 3% in the Ahmed Glaucoma Valve and Baerveldt Glaucoma Implant groups, respectively (P =.04). Conclusions Long-term rates of vision-threatening complications and complications resulting in reoperation were higher in the Baerveldt Glaucoma Implant than in the Ahmed Glaucoma Valve group over 5 years of follow-up.

AB - Purpose To compare the late complications in the Ahmed Baerveldt Comparison Study during 5 years of follow-up. Design Multicenter, prospective randomized clinical trial. Methods setting: Sixteen international clinical centers. study population: Two hundred seventy-six subjects aged 18-85 years with previous intraocular surgery or refractory glaucoma with intraocular pressure of >18 mm Hg. interventions: Ahmed Glaucoma Valve FP7 or Baerveldt Glaucoma Implant BG 101-350. main outcome measures: Late postoperative complications (beyond 3 months), reoperations for complications, and decreased vision from complications. Results Late complications developed in 56 subjects (46.8 ± 4.8 5-year cumulative % ± SE) in the Ahmed Glaucoma Valve group and 67 (56.3 ± 4.7 5-year cumulative % ± SE) in the Baerveldt Glaucoma Implant group (P =.082). The cumulative rates of serious complications were 15.9% and 24.7% in the Ahmed Glaucoma Valve and Baerveldt Glaucoma Implant groups, respectively (P =.034), although this was largely driven by subjects who had tube occlusions in the 2 groups (0.8% in the Ahmed Glaucoma Valve group and 5.7% in the Baerveldt Glaucoma Implant group, P =.037). Both groups had a relatively high incidence of persistent diplopia (12%) and corneal edema (20%), although half of the corneal edema cases were likely due to pre-existing causes other than the aqueous shunt. The incidence of tube erosion was 1% and 3% in the Ahmed Glaucoma Valve and Baerveldt Glaucoma Implant groups, respectively (P =.04). Conclusions Long-term rates of vision-threatening complications and complications resulting in reoperation were higher in the Baerveldt Glaucoma Implant than in the Ahmed Glaucoma Valve group over 5 years of follow-up.

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