Postoperative changes in cerebral metabolism in temporal lobe epilepsy

Marianna V. Spanaki, Leonid Kopylev, Charles DeCarli, William D. Gaillard, Kore Liow, Sharam Fazilat, Shahin Fazilat, Pat Reeves, Susumu Sato, Conrad Kufta, William H. Theodore

Research output: Contribution to journalArticle

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Abstract

Background: Fludeoxyglucose F 18 positron emission tomography (18F-FDG-PET) can detect focal metabolic abnormalities ipsilateral to the seizure focus in 80% of patients with temporal lobe epilepsy (TLE). Regions outside the epileptogenic zone can also be affected. We hypothesized that these remote regions might show altered metabolism, tending to return toward normal values, after surgery. Design: Interictal preoperative and postoperative 18F-FDG-PET metabolism were compared in patients with refractory TLE. Based on pathological findings, disease was classified in the following 3 groups: mesial temporal sclerosis, mass lesions, and no pathological diagnosis. Quantitative PET data analysis was performed using the region-of-interest template previously described. Global normalization was used to adjust for the effect of antiepileptic medication changes. Data were analyzed by Wilcoxon signed rank test and analysis of variance. Setting: The Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health. Patients: Twenty-two patients with refractory TLE. Results: Preoperatively, in all groups, cerebral metabolic rate for glucose was decreased ipsilateral to the resection site in inferior lateral temporal, inferior mesial temporal, and inferior frontal areas and thalamus. Postoperatively, in all groups, cerebral metabolic rate for glucose increased in ipsilateral inferior frontal area and thalamus. In the mesial temporal sclerosis group, we found a statistically significant increase in the contralateral thalamus. Conclusion: Temporal lobe epilepsy is associated with extensive preoperative decreased metabolism in inferior lateral temporal, inferior mesial temporal, and inferior frontal areas and thalamus. Postoperatively, we found increased IF and thalamic metabolism. Seizures may have a reversible effect on brain areas connected with, but remote from, the epileptogenic cortex.

Original languageEnglish (US)
Pages (from-to)1447-1452
Number of pages6
JournalArchives of Neurology
Volume57
Issue number10
StatePublished - 2000
Externally publishedYes

Fingerprint

Temporal Lobe Epilepsy
Thalamus
Fluorodeoxyglucose F18
Sclerosis
Seizures
National Institute of Neurological Disorders and Stroke
Glucose
National Institutes of Health (U.S.)
Nonparametric Statistics
Positron-Emission Tomography
Anticonvulsants
Metabolism
Epilepsy
Analysis of Variance
Reference Values
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Spanaki, M. V., Kopylev, L., DeCarli, C., Gaillard, W. D., Liow, K., Fazilat, S., ... Theodore, W. H. (2000). Postoperative changes in cerebral metabolism in temporal lobe epilepsy. Archives of Neurology, 57(10), 1447-1452.

Postoperative changes in cerebral metabolism in temporal lobe epilepsy. / Spanaki, Marianna V.; Kopylev, Leonid; DeCarli, Charles; Gaillard, William D.; Liow, Kore; Fazilat, Sharam; Fazilat, Shahin; Reeves, Pat; Sato, Susumu; Kufta, Conrad; Theodore, William H.

In: Archives of Neurology, Vol. 57, No. 10, 2000, p. 1447-1452.

Research output: Contribution to journalArticle

Spanaki, MV, Kopylev, L, DeCarli, C, Gaillard, WD, Liow, K, Fazilat, S, Fazilat, S, Reeves, P, Sato, S, Kufta, C & Theodore, WH 2000, 'Postoperative changes in cerebral metabolism in temporal lobe epilepsy', Archives of Neurology, vol. 57, no. 10, pp. 1447-1452.
Spanaki MV, Kopylev L, DeCarli C, Gaillard WD, Liow K, Fazilat S et al. Postoperative changes in cerebral metabolism in temporal lobe epilepsy. Archives of Neurology. 2000;57(10):1447-1452.
Spanaki, Marianna V. ; Kopylev, Leonid ; DeCarli, Charles ; Gaillard, William D. ; Liow, Kore ; Fazilat, Sharam ; Fazilat, Shahin ; Reeves, Pat ; Sato, Susumu ; Kufta, Conrad ; Theodore, William H. / Postoperative changes in cerebral metabolism in temporal lobe epilepsy. In: Archives of Neurology. 2000 ; Vol. 57, No. 10. pp. 1447-1452.
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AU - Spanaki, Marianna V.

AU - Kopylev, Leonid

AU - DeCarli, Charles

AU - Gaillard, William D.

AU - Liow, Kore

AU - Fazilat, Sharam

AU - Fazilat, Shahin

AU - Reeves, Pat

AU - Sato, Susumu

AU - Kufta, Conrad

AU - Theodore, William H.

PY - 2000

Y1 - 2000

N2 - Background: Fludeoxyglucose F 18 positron emission tomography (18F-FDG-PET) can detect focal metabolic abnormalities ipsilateral to the seizure focus in 80% of patients with temporal lobe epilepsy (TLE). Regions outside the epileptogenic zone can also be affected. We hypothesized that these remote regions might show altered metabolism, tending to return toward normal values, after surgery. Design: Interictal preoperative and postoperative 18F-FDG-PET metabolism were compared in patients with refractory TLE. Based on pathological findings, disease was classified in the following 3 groups: mesial temporal sclerosis, mass lesions, and no pathological diagnosis. Quantitative PET data analysis was performed using the region-of-interest template previously described. Global normalization was used to adjust for the effect of antiepileptic medication changes. Data were analyzed by Wilcoxon signed rank test and analysis of variance. Setting: The Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health. Patients: Twenty-two patients with refractory TLE. Results: Preoperatively, in all groups, cerebral metabolic rate for glucose was decreased ipsilateral to the resection site in inferior lateral temporal, inferior mesial temporal, and inferior frontal areas and thalamus. Postoperatively, in all groups, cerebral metabolic rate for glucose increased in ipsilateral inferior frontal area and thalamus. In the mesial temporal sclerosis group, we found a statistically significant increase in the contralateral thalamus. Conclusion: Temporal lobe epilepsy is associated with extensive preoperative decreased metabolism in inferior lateral temporal, inferior mesial temporal, and inferior frontal areas and thalamus. Postoperatively, we found increased IF and thalamic metabolism. Seizures may have a reversible effect on brain areas connected with, but remote from, the epileptogenic cortex.

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