Postnatal Zika virus infection of nonhuman primate infants born to mothers infected with homologous Brazilian Zika virus

Nicholas J. Maness, Blake Schouest, Anil Singapuri, Maria Dennis, Margaret H. Gilbert, Rudolf P. Bohm, Faith Schiro, Pyone P. Aye, Kate Baker, Koen K.A. Van Rompay, Andrew A. Lackner, Myrna C. Bonaldo, Robert V. Blair, Sallie R. Permar, Lark L Schneider Coffey, Antonito T. Panganiban, Diogo Magnani

Research output: Contribution to journalArticle

Abstract

Recent data in a nonhuman primate model showed that infants postnatally infected with Zika virus (ZIKV) were acutely susceptible to high viremia and neurological damage, suggesting the window of vulnerability extends beyond gestation. In this pilot study, we addressed the susceptibility of two infant rhesus macaques born healthy to dams infected with Zika virus during pregnancy. Passively acquired neutralizing antibody titers dropped below detection limits between 2 and 3 months of age, while binding antibodies remained detectable until viral infection at 5 months. Acute serum viremia was comparatively lower than adults infected with the same Brazilian isolate of ZIKV (n = 11 pregnant females, 4 males, and 4 non-pregnant females). Virus was never detected in cerebrospinal fluid nor in neural tissues at necropsy two weeks after infection. However, viral RNA was detected in lymph nodes, confirming some tissue dissemination. Though protection was not absolute and our study lacks an important comparison with postnatally infected infants born to naïve dams, our data suggest infants born healthy to infected mothers may harbor a modest but important level of protection from postnatally acquired ZIKV for several months after birth, an encouraging result given the potentially severe infection outcomes of this population.

Original languageEnglish (US)
Article number12802
JournalScientific reports
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2019

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Primates
Mothers
Viremia
Pregnancy
Viral RNA
Virus Diseases
Infection
Neutralizing Antibodies
Macaca mulatta
Cerebrospinal Fluid
Limit of Detection
Lymph Nodes
Parturition
Viruses
Zika Virus Infection
Zika Virus
Antibodies
Serum
Population

ASJC Scopus subject areas

  • General

Cite this

Maness, N. J., Schouest, B., Singapuri, A., Dennis, M., Gilbert, M. H., Bohm, R. P., ... Magnani, D. (2019). Postnatal Zika virus infection of nonhuman primate infants born to mothers infected with homologous Brazilian Zika virus. Scientific reports, 9(1), [12802]. https://doi.org/10.1038/s41598-019-49209-7

Postnatal Zika virus infection of nonhuman primate infants born to mothers infected with homologous Brazilian Zika virus. / Maness, Nicholas J.; Schouest, Blake; Singapuri, Anil; Dennis, Maria; Gilbert, Margaret H.; Bohm, Rudolf P.; Schiro, Faith; Aye, Pyone P.; Baker, Kate; Van Rompay, Koen K.A.; Lackner, Andrew A.; Bonaldo, Myrna C.; Blair, Robert V.; Permar, Sallie R.; Schneider Coffey, Lark L; Panganiban, Antonito T.; Magnani, Diogo.

In: Scientific reports, Vol. 9, No. 1, 12802, 01.12.2019.

Research output: Contribution to journalArticle

Maness, NJ, Schouest, B, Singapuri, A, Dennis, M, Gilbert, MH, Bohm, RP, Schiro, F, Aye, PP, Baker, K, Van Rompay, KKA, Lackner, AA, Bonaldo, MC, Blair, RV, Permar, SR, Schneider Coffey, LL, Panganiban, AT & Magnani, D 2019, 'Postnatal Zika virus infection of nonhuman primate infants born to mothers infected with homologous Brazilian Zika virus', Scientific reports, vol. 9, no. 1, 12802. https://doi.org/10.1038/s41598-019-49209-7
Maness, Nicholas J. ; Schouest, Blake ; Singapuri, Anil ; Dennis, Maria ; Gilbert, Margaret H. ; Bohm, Rudolf P. ; Schiro, Faith ; Aye, Pyone P. ; Baker, Kate ; Van Rompay, Koen K.A. ; Lackner, Andrew A. ; Bonaldo, Myrna C. ; Blair, Robert V. ; Permar, Sallie R. ; Schneider Coffey, Lark L ; Panganiban, Antonito T. ; Magnani, Diogo. / Postnatal Zika virus infection of nonhuman primate infants born to mothers infected with homologous Brazilian Zika virus. In: Scientific reports. 2019 ; Vol. 9, No. 1.
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