Abstract
Clara cell secretory protein (CCSP) is a protective lung protein that is believed to have antioxidant, immunomodulatory, and anticarcinogenic properties. Evidence suggests that CCSP is involved in mitigating many lung disease states during development including asthma. This study's rationale is to define the distribution and abundance of CCSP in the airway epithelium of the rhesus monkey during postnatal lung development using carefully controlled site-specific morphometric approaches in defined airway regions. Immunoreactive CCSP was found in nonciliated cells and mucous cells, including glands, throughout the airway epithelium at all ages, with proximal and mid-level airways having the highest labeling. Overall airway CCSP levels were low at 1 week and 1 month, doubled between 1 and 3 months, and changed little from 3 months to 3 years. Thus, the critical developmental window for CCSP expression to reach adult levels in the rhesus conducting airways occurs between 1 and 3 months of age.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3016-3024 |
| Number of pages | 9 |
| Journal | Developmental Dynamics |
| Volume | 238 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 2009 |
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Keywords
- Bronchial epithelium
- CC10
- CC16
- Lung
- Macaca mulatta
- SCGB 1A1
ASJC Scopus subject areas
- Developmental Biology
Cite this
Postnatal lung development of rhesus monkey airways : Cellular expression of Clara cell secretory protein. / Coppens, John T.; Plopper, Charles; Murphy, Shannon R.; Van Winkle, Laura S.
In: Developmental Dynamics, Vol. 238, No. 12, 12.2009, p. 3016-3024.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Postnatal lung development of rhesus monkey airways
T2 - Cellular expression of Clara cell secretory protein
AU - Coppens, John T.
AU - Plopper, Charles
AU - Murphy, Shannon R.
AU - Van Winkle, Laura S.
PY - 2009/12
Y1 - 2009/12
N2 - Clara cell secretory protein (CCSP) is a protective lung protein that is believed to have antioxidant, immunomodulatory, and anticarcinogenic properties. Evidence suggests that CCSP is involved in mitigating many lung disease states during development including asthma. This study's rationale is to define the distribution and abundance of CCSP in the airway epithelium of the rhesus monkey during postnatal lung development using carefully controlled site-specific morphometric approaches in defined airway regions. Immunoreactive CCSP was found in nonciliated cells and mucous cells, including glands, throughout the airway epithelium at all ages, with proximal and mid-level airways having the highest labeling. Overall airway CCSP levels were low at 1 week and 1 month, doubled between 1 and 3 months, and changed little from 3 months to 3 years. Thus, the critical developmental window for CCSP expression to reach adult levels in the rhesus conducting airways occurs between 1 and 3 months of age.
AB - Clara cell secretory protein (CCSP) is a protective lung protein that is believed to have antioxidant, immunomodulatory, and anticarcinogenic properties. Evidence suggests that CCSP is involved in mitigating many lung disease states during development including asthma. This study's rationale is to define the distribution and abundance of CCSP in the airway epithelium of the rhesus monkey during postnatal lung development using carefully controlled site-specific morphometric approaches in defined airway regions. Immunoreactive CCSP was found in nonciliated cells and mucous cells, including glands, throughout the airway epithelium at all ages, with proximal and mid-level airways having the highest labeling. Overall airway CCSP levels were low at 1 week and 1 month, doubled between 1 and 3 months, and changed little from 3 months to 3 years. Thus, the critical developmental window for CCSP expression to reach adult levels in the rhesus conducting airways occurs between 1 and 3 months of age.
KW - Bronchial epithelium
KW - CC10
KW - CC16
KW - Lung
KW - Macaca mulatta
KW - SCGB 1A1
UR - http://www.scopus.com/inward/record.url?scp=70949104969&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70949104969&partnerID=8YFLogxK
U2 - 10.1002/dvdy.22132
DO - 10.1002/dvdy.22132
M3 - Article
C2 - 19877270
AN - SCOPUS:70949104969
VL - 238
SP - 3016
EP - 3024
JO - Developmental Dynamics
JF - Developmental Dynamics
SN - 1058-8388
IS - 12
ER -