Postnatal growth of tracheobronchial airways of Sprague-Dawley rats

Dongyoub Lee, Praveen K. Srirama, Christopher Wallis, Anthony S. Wexler

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Rats are widely used for the studies of pulmonary toxicology in both juveniles and adults. To facilitate such studies, investigators have developed models of lung architecture based on manual or computerized airway measurements. However, postnatal growth of conducting airways of rat lungs has never been reported. In this paper, we present conducting airway architecture statistics for male Sprague-Dawley rat lungs at ages 15, 28, 40, and 81days by analyzing CT images from airway silicon casts. Detailed branching characteristics and intersubject variance are presented. This study shows that (i) airway growth in diameter and length is not linear with age, (ii) growth of airway length is faster than that of diameter during the 15-81-day postnatal period, and (iii) asymmetry in airway diameter (ratio of major to minor daughter diameter) increases with age.

Original languageEnglish (US)
Pages (from-to)717-725
Number of pages9
JournalJournal of Anatomy
Volume218
Issue number6
DOIs
StatePublished - Jun 2011

Fingerprint

Sprague Dawley Rats
lungs
Lung
rats
Growth
postpartum period
toxicology
Silicon
silicon
Toxicology
branching
asymmetry
statistics
Research Personnel

Keywords

  • Computed tomography image
  • Conducting airways
  • Lung growth
  • Sprague-Dawley rats

ASJC Scopus subject areas

  • Anatomy
  • Histology
  • Developmental Biology
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Cell Biology

Cite this

Postnatal growth of tracheobronchial airways of Sprague-Dawley rats. / Lee, Dongyoub; Srirama, Praveen K.; Wallis, Christopher; Wexler, Anthony S.

In: Journal of Anatomy, Vol. 218, No. 6, 06.2011, p. 717-725.

Research output: Contribution to journalArticle

Lee, Dongyoub ; Srirama, Praveen K. ; Wallis, Christopher ; Wexler, Anthony S. / Postnatal growth of tracheobronchial airways of Sprague-Dawley rats. In: Journal of Anatomy. 2011 ; Vol. 218, No. 6. pp. 717-725.
@article{7445b58c58a742a7ba7f3093c3e78598,
title = "Postnatal growth of tracheobronchial airways of Sprague-Dawley rats",
abstract = "Rats are widely used for the studies of pulmonary toxicology in both juveniles and adults. To facilitate such studies, investigators have developed models of lung architecture based on manual or computerized airway measurements. However, postnatal growth of conducting airways of rat lungs has never been reported. In this paper, we present conducting airway architecture statistics for male Sprague-Dawley rat lungs at ages 15, 28, 40, and 81days by analyzing CT images from airway silicon casts. Detailed branching characteristics and intersubject variance are presented. This study shows that (i) airway growth in diameter and length is not linear with age, (ii) growth of airway length is faster than that of diameter during the 15-81-day postnatal period, and (iii) asymmetry in airway diameter (ratio of major to minor daughter diameter) increases with age.",
keywords = "Computed tomography image, Conducting airways, Lung growth, Sprague-Dawley rats",
author = "Dongyoub Lee and Srirama, {Praveen K.} and Christopher Wallis and Wexler, {Anthony S.}",
year = "2011",
month = "6",
doi = "10.1111/j.1469-7580.2011.01372.x",
language = "English (US)",
volume = "218",
pages = "717--725",
journal = "Journal of Anatomy",
issn = "0021-8782",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Postnatal growth of tracheobronchial airways of Sprague-Dawley rats

AU - Lee, Dongyoub

AU - Srirama, Praveen K.

AU - Wallis, Christopher

AU - Wexler, Anthony S.

PY - 2011/6

Y1 - 2011/6

N2 - Rats are widely used for the studies of pulmonary toxicology in both juveniles and adults. To facilitate such studies, investigators have developed models of lung architecture based on manual or computerized airway measurements. However, postnatal growth of conducting airways of rat lungs has never been reported. In this paper, we present conducting airway architecture statistics for male Sprague-Dawley rat lungs at ages 15, 28, 40, and 81days by analyzing CT images from airway silicon casts. Detailed branching characteristics and intersubject variance are presented. This study shows that (i) airway growth in diameter and length is not linear with age, (ii) growth of airway length is faster than that of diameter during the 15-81-day postnatal period, and (iii) asymmetry in airway diameter (ratio of major to minor daughter diameter) increases with age.

AB - Rats are widely used for the studies of pulmonary toxicology in both juveniles and adults. To facilitate such studies, investigators have developed models of lung architecture based on manual or computerized airway measurements. However, postnatal growth of conducting airways of rat lungs has never been reported. In this paper, we present conducting airway architecture statistics for male Sprague-Dawley rat lungs at ages 15, 28, 40, and 81days by analyzing CT images from airway silicon casts. Detailed branching characteristics and intersubject variance are presented. This study shows that (i) airway growth in diameter and length is not linear with age, (ii) growth of airway length is faster than that of diameter during the 15-81-day postnatal period, and (iii) asymmetry in airway diameter (ratio of major to minor daughter diameter) increases with age.

KW - Computed tomography image

KW - Conducting airways

KW - Lung growth

KW - Sprague-Dawley rats

UR - http://www.scopus.com/inward/record.url?scp=79955524815&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955524815&partnerID=8YFLogxK

U2 - 10.1111/j.1469-7580.2011.01372.x

DO - 10.1111/j.1469-7580.2011.01372.x

M3 - Article

C2 - 21534951

AN - SCOPUS:79955524815

VL - 218

SP - 717

EP - 725

JO - Journal of Anatomy

JF - Journal of Anatomy

SN - 0021-8782

IS - 6

ER -