Postnatal development of the lamina reticularis in primate airways

Michael J. Evans, Michelle V. Fanucchi, Charles Plopper, Dallas M. Hyde

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The basement membrane zone (BMZ) appears as three component layers: the lamina lucida, lamina densa, and lamina reticularis. The laminas lucida and densa are present during all stages of development. The lamina reticularis appears during postnatal development. Collagens I, III, and V form heterogeneous fibers that account for the thickness of the lamina reticularis. Additionally, there are three proteoglycans considered as integral components of the BMZ: perlecan, collagen XVIII, and bamacan. Perlecan is the predominant heparan sulfate proteoglycan in the airway BMZ. It is responsible for many of the functions attributed to the BMZ, in particular, trafficking of growth factors and cytokines between epithelial and mesenchymal cells. Growth factor binding sites on perlecan include FGF-1, FGF-2, FGF-7, FGF-10, PDGF, HGF, HB-EGF, VEGF, and TGF-β. Growth factors pass through the BMZ when moving between the epithelial and mesenchymal cell layers. They move by rapid reversible binding with sites on both the heparan sulfate chains and core protein of perlecan. In this manner, perlecan regulates movement of growth factors between tissues. Another function of the BMZ is storage and regulation of FGF-2. FGF-2 has been shown to be involved with normal growth and thickening of the BMZ. Thickening of the BMZ is a feature of airway remodeling in asthma. It may have a positive effect by protecting against airway narrowing and air trapping. Conversely, it may have a negative effect by influencing trafficking of growth factors in the epithelial mesenchymal trophic unit. However, currently the significance of BMZ thickening is not known.

Original languageEnglish (US)
Pages (from-to)947-954
Number of pages8
JournalAnatomical Record
Volume293
Issue number6
DOIs
StatePublished - Jun 2010

Fingerprint

postnatal development
laminae (animals)
basement membrane
Basement Membrane
primate
Primates
membrane
growth factors
Intercellular Signaling Peptides and Proteins
Fibroblast Growth Factor 2
trafficking
proteoglycans
collagen
Collagen Type XVIII
Epithelial Cells
Binding Sites
sulfate
Airway Remodeling
Fibroblast Growth Factor 1
Heparan Sulfate Proteoglycans

Keywords

  • Basement membrane zone
  • Collagen
  • Fibroblast growth factor-2
  • Lamina reticularis
  • Perlecan

ASJC Scopus subject areas

  • Anatomy
  • Histology
  • Ecology, Evolution, Behavior and Systematics
  • Biotechnology

Cite this

Postnatal development of the lamina reticularis in primate airways. / Evans, Michael J.; Fanucchi, Michelle V.; Plopper, Charles; Hyde, Dallas M.

In: Anatomical Record, Vol. 293, No. 6, 06.2010, p. 947-954.

Research output: Contribution to journalArticle

Evans, Michael J. ; Fanucchi, Michelle V. ; Plopper, Charles ; Hyde, Dallas M. / Postnatal development of the lamina reticularis in primate airways. In: Anatomical Record. 2010 ; Vol. 293, No. 6. pp. 947-954.
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