Postinjury scopolamine administration in experimental traumatic brain injury

Bruce G Lyeth, Mikelene Ray, Robert J. Hamm, James Schnabel, Joseph J. Saady, Alphonse Poklis, Larry W. Jenkins, Steven K. Gudeman, Ronald L. Hayes

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

A single bolus dose of scopolamine (1.0 mg/kg) or saline (equal volume) was injected (i.p.) at 15, 30 or 60 min after fluid percussion traumatic brain injury in the rat. Scopolamine administered at 15 min postinjury significantly reduced beam walking deficits and body weight loss assessed for 5 days after injury. Scopolamine treatment at 30 or 60 min postinjury had no effect on behavioral outcome assessed for 5 days after injury. Plasma concentrations of scopolamine were measured with a radioreceptor assay. The plasma half-life for scopolamine was 21.6 min in injured rats and 17.3 min in normal rats (P < 0.05). These results, along with evidence from previous studies, suggest that a brief period of excessive neuronal excitation can produce relatively long-lasting behavioral deficits. The temporal effectiveness of receptor antagonist intervention in this process appears to be brief.

Original languageEnglish (US)
Pages (from-to)281-286
Number of pages6
JournalBrain Research
Volume569
Issue number2
DOIs
StatePublished - Jan 13 1992
Externally publishedYes

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Keywords

  • Acetylcholine
  • Behavior
  • Muscarine
  • Radioreceptor assay
  • Rat
  • Scopolamine
  • Traumatic brain injury

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Lyeth, B. G., Ray, M., Hamm, R. J., Schnabel, J., Saady, J. J., Poklis, A., Jenkins, L. W., Gudeman, S. K., & Hayes, R. L. (1992). Postinjury scopolamine administration in experimental traumatic brain injury. Brain Research, 569(2), 281-286. https://doi.org/10.1016/0006-8993(92)90640-U