Post-vaccinal distemper encephalitis in two Border Collie cross littermates

R. A. Fairley, O. Knesl, Patricia Pesavento, B. C. Elias

Research output: Contribution to journalArticle

Abstract

Abstract: CASE HISTORY: One 4.5-month-old male Border Collie cross presented with aggression and seizures in October 2006. A 16-month-old, female, spayed Border Collie cross presented with hypersalivation and a dropped jaw and rapidly became stuporous in September 2007. The dogs were littermates and developed acute neurological signs 5 and 27 days, respectively, after vaccination with different modified live vaccines containing canine distemper virus. HISTOPATHOLOGICAL FINDINGS: Sections of brain in both dogs showed evidence of encephalitis mainly centred on the grey matter of brainstem nuclei, where there was extensive and intense parenchymal and perivascular infiltration of histiocytes and lymphocytes. Intra-nuclear and intra-cytoplasmic inclusions typical of distemper were plentiful and there was abundant labelling for canine distemper virus using immunohistochemistry. DIAGNOSIS: Post-vaccinal canine distemper. CLINCIAL RELEVANCE: Post-vaccinal canine distemper has mainly been attributed to virulent vaccine virus, but it may also occur in dogs whose immunologic nature makes them susceptible to disease induced by a modified-live vaccine virus that is safe and protective for most dogs.

Original languageEnglish (US)
Pages (from-to)117-120
Number of pages4
JournalNew Zealand Veterinary Journal
Volume63
Issue number2
DOIs
StatePublished - Mar 4 2015

Fingerprint

Distemper
Acute Disseminated Encephalomyelitis
Collie
distemper
encephalitis
Canine Distemper Virus
Dogs
canine distemper
Canine distemper virus
Vaccines
dogs
live vaccines
Sialorrhea
histiocytes
Viruses
cytoplasmic inclusions
viruses
Histiocytes
biological resistance
Inclusion Bodies

Keywords

  • canine distemper
  • Dog
  • encephalitis
  • IHC
  • vaccine

ASJC Scopus subject areas

  • veterinary(all)
  • Medicine(all)

Cite this

Post-vaccinal distemper encephalitis in two Border Collie cross littermates. / Fairley, R. A.; Knesl, O.; Pesavento, Patricia; Elias, B. C.

In: New Zealand Veterinary Journal, Vol. 63, No. 2, 04.03.2015, p. 117-120.

Research output: Contribution to journalArticle

Fairley, R. A. ; Knesl, O. ; Pesavento, Patricia ; Elias, B. C. / Post-vaccinal distemper encephalitis in two Border Collie cross littermates. In: New Zealand Veterinary Journal. 2015 ; Vol. 63, No. 2. pp. 117-120.
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