POST-TRAUMATIC OCULAR LYMPHOMA IN THREE RABBITS (ORYCTOLAGUS CUNICULUS)

Krista A. Keller, David Guzman, Christopher Reilly, Beth Valentine, Felicia D. Duke Boynton, Erin M. Scott, Richard R. Dubielzig

Research output: Contribution to journalArticle

Abstract

This report describes post-traumatic ocular lymphoma in 3 companion rabbits; 2 rabbits with unilateral disease and 1 with bilateral disease. Historical findings suggestive of a traumatic event included either external unilateral ocular trauma or bilateral phacoemulsification. Severe corneal changes, presence of an anterior chamber mass(es), low intraocular pressures, and ocular discomfort were noted on ophthalmic examinations. All eyes were treated for variable courses with standard ophthalmic topical medications (antibiotic, anti-inflammatories, and steroid) and systemic anti-inflammatories. Based upon progression of disease, all affected eyes were ultimately enucleated; lenticular capsular rupture and a round cell neoplasm effacing normal structures with variable mitotic indices were noted on histopathology. Neoplastic lymphocytes strongly expressed CD79a via immunohistochemistry and lacked expression for CD3, indicating B lymphocyte lineage and not of T cell lineage. A single animal had evidence of local metastasis to a regional lymph node. Post-traumatic sarcomas have been reported in this species previously, however, these cases are the first reports of this novel round cell variant, named post-traumatic ocular lymphoma due to the B cell lineage confirmed through immunohistochemistry. Clinicians should be aware of this clinical presentation and the possibility of metastasis when evaluating ocular pathology in this species.

LanguageEnglish (US)
Pages154-161
Number of pages8
JournalJournal of Exotic Pet Medicine
Volume28
DOIs
StatePublished - Jan 1 2019

Fingerprint

Oryctolagus cuniculus
lymphoma
Lymphoma
eyes
rabbits
Rabbits
Cell Lineage
metastasis
B-lymphocytes
immunohistochemistry
B-Lymphocytes
Anti-Inflammatory Agents
Immunohistochemistry
Neoplasm Metastasis
life events
Mitotic Index
Phacoemulsification
sarcoma
Anterior Chamber
Intraocular Pressure

Keywords

  • lymphoma
  • neoplasia
  • ophthalmic
  • post-traumatic sarcoma
  • rabbit

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Keller, K. A., Guzman, D., Reilly, C., Valentine, B., Duke Boynton, F. D., Scott, E. M., & Dubielzig, R. R. (2019). POST-TRAUMATIC OCULAR LYMPHOMA IN THREE RABBITS (ORYCTOLAGUS CUNICULUS). Journal of Exotic Pet Medicine, 28, 154-161. https://doi.org/10.1053/j.jepm.2018.02.041

POST-TRAUMATIC OCULAR LYMPHOMA IN THREE RABBITS (ORYCTOLAGUS CUNICULUS). / Keller, Krista A.; Guzman, David; Reilly, Christopher; Valentine, Beth; Duke Boynton, Felicia D.; Scott, Erin M.; Dubielzig, Richard R.

In: Journal of Exotic Pet Medicine, Vol. 28, 01.01.2019, p. 154-161.

Research output: Contribution to journalArticle

Keller, KA, Guzman, D, Reilly, C, Valentine, B, Duke Boynton, FD, Scott, EM & Dubielzig, RR 2019, 'POST-TRAUMATIC OCULAR LYMPHOMA IN THREE RABBITS (ORYCTOLAGUS CUNICULUS)' Journal of Exotic Pet Medicine, vol. 28, pp. 154-161. https://doi.org/10.1053/j.jepm.2018.02.041
Keller, Krista A. ; Guzman, David ; Reilly, Christopher ; Valentine, Beth ; Duke Boynton, Felicia D. ; Scott, Erin M. ; Dubielzig, Richard R. / POST-TRAUMATIC OCULAR LYMPHOMA IN THREE RABBITS (ORYCTOLAGUS CUNICULUS). In: Journal of Exotic Pet Medicine. 2019 ; Vol. 28. pp. 154-161.
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