Possible role of Epoxyeicosatrienoic acid in prevention of oxidative stress mediated neuroinflammation in Parkinson disorders

Navya Lakkappa, Praveen T. Krishnamurthy, Bruce D. Hammock, D. Velmurugan, M. M Srinivas Bharath

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Parkinson's disease (PD) is a multifactorial neurodegenerative disease involving oxidative stress, neuroinflammation and apoptosis. Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites and they play a role in cytoprotection by modulating various cell signaling pathways. This cytoprotective role of EETs are well established in cerebral stroke, cardiac failure, and hypertension, and it is due to their ability to attenuate oxidative stress, endoplasmic reticulum stress, inflammation, caspase activation and apoptosis. The actions of EETs in brain closely parallel the effects which is observed in the peripheral tissues. Since many of these effects could potentially contribute to neuroprotection, EETs are, therefore, one of the potential therapeutic candidates in PD. Therefore, by increasing the half life of endogenous EETs in vivo via inhibition of sEH, its metabolizing enzyme can, therefore, constitutes an important therapeutic strategy in PD.

Original languageEnglish (US)
Pages (from-to)161-165
Number of pages5
JournalMedical Hypotheses
Volume93
DOIs
StatePublished - 2016

Keywords

  • Apoptosis
  • Cytochrome P450
  • EETs
  • Neuroinflammation
  • Neuroprotection
  • Oxidative stress
  • PD
  • sEH

ASJC Scopus subject areas

  • Medicine(all)

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