Possible effects of the 1990-1995 war in Croatia on thyroid cancer epidemiology

D. Simunovic, I. Cvjetko, V. Gladic, M. Elez, M. Glasnovic, T. Lenicek, M. Vucic, Mirna Lechpammer, H. Cupic, M. Strnad, Z. Kusic, B. Kruslin, M. Belicza

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


A Thyroid Cancer Registry containing data of patients treated at our department during a 20-year period (1980-1999) has been established. The aim of the study was to analyze the possible effects of the 1990-1995 war in Croatia on the prevalence, type, and age and sex distribution of thyroid carcinoma. Three different 2-year periods were analyzed: distant prewar (1980-1981), immediate prewar (1989-1990) and postwar (1998-1999) period. There was no statistically significant difference in age at diagnosis and sex ratio among the three study periods. The incidence of follicular cancer was at the upper limit for countries with normal iodine uptake when the 20-year period was analyzed, however, in the 1980-1981 period follicular cancer accounted for 34.9%, and in 1998-99 for only 2.8% of all cases. Papillary cancer was diagnosed in less advanced stages than others. Five-year survival for papillary, follicular and anaplastic cancer was 100%, 100% and 0%, respectively. Analysis of the 2-year periods for all cancer types except anaplastic cancer showed the mean age at onset to be on a decrease. In the 1998-1999 period, papillary cancer was diagnosed in a more advanced stage. The number of follicular cancer cases decreased from 22 in 1980-1981 to 3 in 1989-1990 and 2 in 1998-1999. Analysis of the epidemiology of thyroid cancer in the pre- and post-Chernobyl period did not reveal any increase in the number of papillary cancer in younger patients. It was concluded that in the postwar period, patients presented in more advanced stages of the disease. However, the effects of war on the epidemiology of thyroid carcinoma and other malignant tumors should be further investigated.

Original languageEnglish (US)
Pages (from-to)155-160
Number of pages6
JournalActa Clinica Croatica
Issue number3
StatePublished - 2000
Externally publishedYes


  • Croatia, epidemiology
  • Risk factors
  • Thyroid neoplasms, epidemiology
  • War

ASJC Scopus subject areas

  • Medicine(all)


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